Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870774 | 0.89 | ACHE (0.40) | ACHEMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9871963 | 0.87 | HTT (0.40) | CYP1A2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9872191 | 0.86 | MAPT (0.38) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9870642 | 0.82 | LMNA (0.44) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL8793570 | 0.81 | LMNA (0.45) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9871188 | 0.77 | KDM4E (0.37) | CYP1A2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL10964096 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1GAAPOLBUSP2NPSR1 | |
| SCHEMBL9872358 | 0.73 | ALDH1A1 (0.36) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9872179 | 0.72 | MAPT (0.33) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9871763 | 0.71 | ALDH1A1 (0.35) | MAPTALDH1A1KDM4EHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | claimed |
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | disclosed |