Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870642 | 0.89 | LMNA (0.44) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL8793570 | 0.88 | LMNA (0.45) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL9871084 | 0.86 | APP (0.37) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL9871963 | 0.83 | HTT (0.40) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL9870774 | 0.76 | ACHE (0.40) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL9871188 | 0.73 | KDM4E (0.37) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL10964096 | 0.72 | SMN1; SMN2 (0.39) | ALDH1A1GAAPOLBUSP2NPSR1 | |
| SCHEMBL8792583 | 0.70 | HTT (0.51) | POLBHSD17B10HTTTDP1KMT2A | |
| SCHEMBL9872358 | 0.69 | ALDH1A1 (0.36) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL9872179 | 0.69 | MAPT (0.33) | MAPTKDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | disclosed |