Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PPOX | P50336 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879337 | 0.85 | L3MBTL1 (0.48) | NPC1GAAMAOAPOLBL3MBTL1 | |
| SCHEMBL9873170 | 0.83 | NPC1 (0.37) | NPC1GAAMAOALMNAPPOX | |
| SCHEMBL8599602 | 0.82 | PPOX (0.45) | NPC1GAAMAOALMNAPPOX | |
| SCHEMBL9769754 | 0.81 | NR1I2 (0.41) | NPC1GAAMAOATAAR1LMNA | |
| SCHEMBL9684658 | 0.81 | L3MBTL1 (0.44) | NPC1GAAMAOALMNAPOLB | |
| SCHEMBL1224878 | 0.80 | NPC1 (0.67) | NPC1GAATAAR1LMNAPPOX | |
| SCHEMBL29283664 | 0.79 | ACLY (0.37) | TAAR1LMNAPPOXPOLBL3MBTL1 | |
| SCHEMBL8604315 | 0.79 | CSNK2A1 (0.49) | NPC1GAAMAOAPPOXPOLB | |
| SCHEMBL8876498 | 0.78 | GAA (0.44) | NPC1GAAMAOALMNAL3MBTL1 | |
| SCHEMBL8599263 | 0.78 | GLA (0.50) | NPC1GAAMAOAPPOXPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240336613-A1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. | 2024-10-10 | — | — | US | disclosed |
| CN-118159539-A | Heteroaryl compounds for the treatment of huntington's disease | PTC医疗公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-4377317-A1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009816-A1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| US-5017213-A | Herbicides | NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0351641-A1 | 1-Phenylpyrrole | NIHON BAYER AGROCHEM K.K. (JP) | 1990-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240336613-A1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | HTT, HYPK, FH | NPC1 57/4885GAA 7/4885MAOA 279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.