Sugi Predict

Sugi Predict / Compounds / Biotin

Biotin

Biotin

SCHEMBL987288

CCCCCC(N)=O.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.79
▸ MEN1 O00255 1/20 0.79
▸ ABL1 P00519 1/20 0.79
▸ LMNA P02545 1/20 0.79
▸ PKM P14618 1/20 0.79
▸ IDE P14735 1/20 0.79
▸ MAPK1 P28482 1/20 0.79
▸ KMT2A Q03164 1/20 0.79
▸ RIN1 Q13671 1/20 0.79
▸ L3MBTL1 Q9Y468 1/20 0.79
▸ HLCS P50747 6/20 0.72
▸ CA12 O43570 7/20 0.50
▸ CA1 P00915 7/20 0.50
▸ CA2 P00918 7/20 0.50
▸ CA9 Q16790 7/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hexanoate SCHEMBL4243024 1.00 TDP1 (0.79) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL8651197 0.95 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL6033491 0.95 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL8672968 0.94 TDP1 (0.85) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23722253 0.94 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Stearic Acid SCHEMBL10828834 0.93 TDP1 (0.83) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL4957081 0.93 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL3518095 0.93 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL27671459 0.93 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL715457 0.92 TDP1 (0.77) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0203959-B1 NUCLEOTIDE ANALOGS FOR NUCLEIC ACID LABELING AND DETECTION LIFE TECHNOLOGIES, INC. (US) 1992-09-09 — — EP claimed
US-4478914-A SURFACE MODIFICATION GIESE ROGER W 1984-10-23 — — US claimed
US-RE31712-E IMMUNOASSAY; IMMOBILIZED ENZYMES Giese, Roger W. (US) 1984-10-23 — — US claimed
US-4282287-A Biochemical avidin-biotin multiple-layer system GIESE ROGER W 1981-08-04 — — US claimed
WO-2024100604-A1 METHODS FOR MANUFACTURING ENGINEERED IMMUNE CELLS JUNO THERAPEUTICS GMBH (DE) 2024-05-16 — — WO disclosed
US-20240150431-A1 MHC Multimers, Methods for Their Generation, Labeling and Use DAKO DENMARK APS (DK) 2024-05-09 — — US disclosed
US-20240101613-A1 OLIGOMERIC PARTICLE REAGENTS AND METHODS OF USE THEREOF JUNO THERAPEUTICS GMBH (DE) 2024-03-28 — — US disclosed
US-20240093300-A1 METHYLATED DNA FRAGMENT ENRICHMENT, METHODS, COMPOSITIONS AND KITS Grail, Inc. 2024-03-21 — — US disclosed
US-20240047098-A1 POLYMER-SILICA HYBRID PDOTS AND METHODS OF USE THEREOF UNIVERSITY OF WASHINGTON (US) 2024-02-08 — — US disclosed
US-11866465-B2 Oligomeric particle reagents and methods of use thereof JUNO THERAPEUTICS GMBH (DE) 2024-01-09 — — US disclosed
EP-3988631-B1 POLYMER-SILICA HYBRID PDOTS UNIV WASHINGTON (US) 2023-11-22 — — EP disclosed
US-11823809-B2 Polymer-silica hybrid pdots and methods of use thereof UNIVERSITY OF WASHINGTON (US) 2023-11-21 — — US disclosed
US-5731153-A DIANGOSIS OF CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-03-24 — — US disclosed
WO-1997029114-A1 BIOTIN-CONTAINING COMPOUNDS, BIOTINYLATION REAGENTS AND METHODS BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON (US) 1997-08-14 — — WO disclosed
US-5616465-A Detection and isolation of nucleic acid sequences using competitive hybridization probes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-04-01 — — US disclosed
EP-0218962-A1 Improved biotinylated peroxidase MILES INC. (US) 1987-04-22 — — EP disclosed
US-4656252-A Amidobiotin compounds useful in a avidin-biotin multiple layering process GIESE ROGER W 1987-04-07 — — US disclosed
US-4478914-A SURFACE MODIFICATION GIESE ROGER W 1984-10-23 — — US disclosed
US-RE31712-E IMMUNOASSAY; IMMOBILIZED ENZYMES Giese, Roger W. (US) 1984-10-23 — — US disclosed
US-4282287-A Biochemical avidin-biotin multiple-layer system GIESE ROGER W 1981-08-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11866465-B2 Oligomeric particle reagents and methods of use thereof CD14, MSH2, CD4 TDP1 2306/4885MEN1 862/4885ABL1 4250/4885
US-11823809-B2 Polymer-silica hybrid pdots and methods of use thereof MSN, PDCD6IP, PDCD10 TDP1 877/4885MEN1 3018/4885ABL1 2328/4885
US-20240150431-A1 MHC Multimers, Methods for Their Generation, Labeling and Use MICA, CD74, HLA-DRB1 TDP1 2892/4885MEN1 2127/4885ABL1 3620/4885
US-20240101613-A1 OLIGOMERIC PARTICLE REAGENTS AND METHODS OF USE THEREOF CD14, MSH2, LY96 TDP1 2386/4885MEN1 824/4885ABL1 3969/4885
US-20240047098-A1 POLYMER-SILICA HYBRID PDOTS AND METHODS OF USE THEREOF MSN, PDCD6IP, PDCD10 TDP1 877/4885MEN1 3018/4885ABL1 2328/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.