Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.47 |
| ▸ | SCN4A | P35499 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | HRH2 | P25021 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9874973 | 0.83 | PDK1 (0.52) | PDK1LMNAPOLBGAAMAPT | |
| SCHEMBL13483223 | 0.81 | PDK1 (0.66) | PDK1LMNAMAPTHTTHSD17B10 | |
| SCHEMBL1030772 | 0.79 | PDK1 (0.71) | PDK1LMNAPOLBGAAMAPT | |
| Bromide SCHEMBL1030770 | 0.78 | PDK1 (0.70) | PDK1LMNAPOLBGAAMAPT | |
| SCHEMBL3025573 | 0.77 | SCN4A (0.62) | LMNAPOLBGAAMAPTTSHR | |
| SCHEMBL9872176 | 0.77 | SCN3A (0.52) | LMNAPOLBGAAMAPTTSHR | |
| SCHEMBL3537545 | 0.76 | PDK1 (0.56) | PDK1LMNAMAPTHTTHSD17B10 | |
| SCHEMBL31214169 | 0.75 | SCN4A (0.67) | SCN3ASCN4ADRD3DRD2HRH2 | |
| SCHEMBL1028051 | 0.75 | PDK1 (0.58) | PDK1LMNAMAPTTSHRHTT | |
| SCHEMBL1028052 | 0.75 | PDK1 (0.58) | PDK1LMNAMAPTTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2007-08-16 | — | — | US | disclosed |
| US-4988699-A | Treatment of psychological disorders such as schizophrenia, as antipsychotic agents and hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1991-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | CYP11B2, CYP11B1, CYP4A11 | PDK1 288/4885LMNA 671/4885POLB 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.