Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872530 | 0.86 | ALDH1A1 (0.35) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2271379 | 0.86 | ALDH1A1 (0.45) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9879478 | 0.83 | MAPT (0.45) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9879581 | 0.83 | GAA (0.49) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9319284 | 0.79 | KEAP1 (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2AGRIN2D | |
| SCHEMBL9319282 | 0.79 | MAPT (0.56) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| Carbromal SCHEMBL9873682 | 0.77 | — | — | |
| SCHEMBL9425140 | 0.75 | KDM4E (0.56) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL258457 | 0.74 | ALDH1A1 (0.43) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL70017 | 0.73 | ALDH1A1 (0.61) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037983-A | 6,7-dihydroxyquinoxalines as intermediates to beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1991-08-06 | — | — | US | disclosed |
| US-4904775-A | Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1990-02-27 | — | — | US | disclosed |
| EP-0342423-A2 | Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics | E.R. SQUIBB & SONS, INC. (US) | 1989-11-23 | — | — | EP | disclosed |
| EP-0303286-A1 | 2-Oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines | E.R. Squibb & Sons, Inc. (US) | 1989-02-15 | — | — | EP | disclosed |
| US-4777252-A | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines | E. R. SQUIBB & SONS, INC. (US) | 1988-10-11 | — | — | US | disclosed |