Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128570 | 0.87 | HRH1 (0.56) | SLC6A2SLC6A4SLC6A3EPHX2LMNA | |
| Ammonia Solution, Strong SCHEMBL28849214 | 0.84 | HRH1 (0.54) | SLC6A2SLC6A4SLC6A3EPHX2LMNA | |
| SCHEMBL16382880 | 0.83 | SLC6A3 (0.49) | SLC6A2SLC6A4SLC6A3EPHX2PRKACA | |
| SCHEMBL8699682 | 0.82 | TBXAS1 (0.60) | SLC6A2SLC6A4SLC6A3EPHX2LMNA | |
| SCHEMBL29173261 | 0.79 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3EPHX2LMNA | |
| SCHEMBL5604418 | 0.77 | LMNA (0.53) | SLC6A2SLC6A3LMNAHRH1TRPA1 | |
| SCHEMBL5490855 | 0.77 | CHRNB2 (0.57) | SLC6A2SLC6A4SLC6A3PRKACACDK8 | |
| SCHEMBL6191029 | 0.76 | HRH1 (0.77) | SLC6A2SLC6A4SLC6A3EPHX2HRH1 | |
| SCHEMBL31676679 | 0.76 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3EPHX2PRKACA | |
| SCHEMBL6699187 | 0.75 | CYP19A1 (0.49) | LMNAHRH1CYP19A1TRPA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |