SCHEMBL9875589

SCHEMBL9875589

Cc1c(-c2ccc(Cl)cc2Cl)nc(C#N)n1S(=O)(=O)N(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.39
KDM4E B2RXH2 3/20 0.39
NPSR1 Q6W5P4 1/20 0.39
MCOLN3 Q8TDD5 2/20 0.38
MAPT P10636 2/20 0.38
USP2 O75604 1/20 0.38
POLB P06746 1/20 0.38
ALOX12 P18054 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
USP8 P40818 2/20 0.37
USP7 Q93009 2/20 0.37
USP47 Q96K76 1/20 0.37
CNR1 P21554 7/20 0.37
CNR2 P34972 6/20 0.37
HSD11B1 P28845 1/20 0.36
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9876241 0.78 LMNA (0.41) HPGDKDM4ENPSR1MCOLN3MAPT
SCHEMBL9077271 0.74 SMN1; SMN2 (0.42) HPGDKDM4EMCOLN3MEN1LMNA
SCHEMBL9520829 0.74 PTGS2 (0.39) HPGDKDM4ENPSR1MAPTUSP2
SCHEMBL9074842 0.74 SMN1; SMN2 (0.42) HPGDKDM4ENPSR1MCOLN3MAPT
SCHEMBL932694 0.71 KMT2A (0.38) HPGDKDM4ENPSR1MAPTPOLB
SCHEMBL9323989 0.69 TSHR (0.49) HPGDKDM4ENPSR1POLBHSD17B10
SCHEMBL9519740 0.69 PTGS2 (0.39) HPGDKDM4ENPSR1POLBMEN1
SCHEMBL9077201 0.69 KDM4E (0.40) HPGDKDM4EMAPTPOLBMEN1
SCHEMBL9519745 0.67 SMN1; SMN2 (0.33) KDM4EGAA
SCHEMBL10832908 0.67 SMN1; SMN2 (0.33) KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5045557-A Imidazable fungicides and use thereof SCHERING AGROCHEMICALS LTD. (GB) 1991-09-03 US disclosed
EP-0284277-A1 Cyanoimidazole fungicides AgrEvo UK Limited (GB) 1988-09-28 EP disclosed