Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11486845 | 0.87 | SMN1; SMN2 (0.85) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9876838 | 0.84 | AKR1C3 (0.64) | SMN1; SMN2ALDH1A1NPC1PARP10KDM4E | |
| SCHEMBL10412775 | 0.84 | PKM (0.64) | MEN1KMT2AATMNPC1RAB9A | |
| SCHEMBL19533698 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL125680 | 0.82 | HSP90AA1 (0.54) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL3282793 | 0.79 | HPGD (0.50) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL23169174 | 0.79 | MAPT (0.61) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL3305633 | 0.79 | HPGD (0.62) | ALDH1A1HPGDMEN1KMT2AATM | |
| SCHEMBL12528013 | 0.78 | HSD17B1 (0.59) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9877598 | 0.78 | ALOX5 (0.68) | PARP10SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |