Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877920 | 0.89 | CYP19A1 (0.44) | CYP19A1POLBCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL9878201 | 0.81 | KAT2B (0.46) | CYP19A1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9877591 | 0.80 | ALDH1A1 (0.49) | LMNANT5EALDH1A1PDE2APDE5A | |
| SCHEMBL9878142 | 0.80 | NT5E (0.61) | POLBSMN1; SMN2NT5EALDH1A1MAPT | |
| SCHEMBL9877927 | 0.80 | KMT2A (0.54) | CYP19A1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9878782 | 0.79 | RAPGEF4 (0.41) | POLBNT5EALDH1A1MAPTCYP3A4 | |
| SCHEMBL10772754 | 0.78 | POLB (0.47) | CYP19A1POLBCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL9877903 | 0.78 | ALDH1A1 (0.59) | CYP19A1POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9877681 | 0.76 | ALDH1A1 (0.52) | SMN1; SMN2LMNAALDH1A1TDP1HTT | |
| SCHEMBL10713418 | 0.76 | MAPT (0.55) | CYP19A1CRHBPCRHR2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992589-A | Substituted phenyl hydroxyethyl sulfones, and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-02-12 | — | — | US | disclosed |