Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9876622 | 0.95 | HTR7 (0.48) | HTR7ACHEDRD2DRD4DRD3 | |
| SCHEMBL9788764 | 0.81 | ACHE (0.46) | ACHEKDM4E | |
| SCHEMBL9879857 | 0.80 | DRD3 (0.53) | HTR7ACHEDRD2HTR2BDRD4 | |
| SCHEMBL9788796 | 0.77 | DRD2 (0.56) | DRD2DRD4DRD3 | |
| Oxalic Acid SCHEMBL9788820 | 0.76 | ALDH1A1 (0.52) | HTR7DRD2HTR2BDRD4DRD3 | |
| SCHEMBL9788769 | 0.75 | DRD2 (0.58) | ACHEDRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL9788754 | 0.74 | DRD2 (0.52) | HTR7ACHEDRD2HTR2BDRD4 | |
| Oxalic Acid SCHEMBL9788758 | 0.71 | ALDH1A1 (0.57) | DRD2DRD4DRD3KDM4EALDH1A1 | |
| SCHEMBL9788787 | 0.71 | DRD2 (0.44) | ACHEDRD2DRD4DRD3 | |
| SCHEMBL9788786 | 0.70 | DRD2 (0.52) | HTR7ACHEDRD2HTR2BDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008264-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-16 | — | — | US | claimed |
| US-5008264-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-16 | — | — | US | disclosed |
| US-4980365-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-12-25 | — | — | US | disclosed |
| EP-0299349-A2 | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-01-18 | — | — | EP | disclosed |