Sugi Predict

Sugi Predict / Compounds / SCHEMBL988036

SCHEMBL988036

SCHEMBL988036

NS(=O)(=O)Cc1ccncc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 4/20 0.60
▸ CA1 P00915 3/20 0.60
▸ CA5A P35218 3/20 0.60
▸ CA9 Q16790 1/20 0.60
▸ KIF11 P52732 1/20 0.50
▸ LOXL2 Q9Y4K0 2/20 0.48
▸ CA7 P43166 2/20 0.41
▸ CA5B Q9Y2D0 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ CYP2D6 P10635 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ LMNA P02545 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ NAMPT P43490 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28476775 0.80 LOXL2 (0.46) LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL4250874 0.77 RECQL (0.59) CA2CA1CA5ALOXL2CA7
SCHEMBL2101858 0.76 L3MBTL1 (0.43) LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL496725 0.76 LOXL2 (0.48) CA2CA1CA5ALOXL2CA7
SCHEMBL1457326 0.76 LOXL2 (0.42) LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL1272513 0.76 LOXL2 (0.42) LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL1416213 0.76 LOXL2 (0.54) CA2CA1CA5ACA9KIF11
Phenylmethanesulfonamide SCHEMBL7371 0.75 CA2 (1.00) CA2CA1CA5ACA9KIF11
Hydrochloric Acid SCHEMBL1500761 0.74 LOXL2 (0.41) LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL5696908 0.74 L3MBTL1 (0.46) LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024131893-A1 IRE1α SMALL MOLECULE INHIBITORS SHANGHAI YI ZHONG XING BIOTECHNOLOGY CO., LTD. (CN) 2024-06-27 — — WO claimed
WO-2024131893-A1 IRE1α SMALL MOLECULE INHIBITORS SHANGHAI YI ZHONG XING BIOTECHNOLOGY CO., LTD. (CN) 2024-06-27 — — WO disclosed
US-10851098-B2 Azole amides and amines as alpha v integrin inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2020-12-01 — — US disclosed
EP-3388425-B1 AMINOAZOLE DERIVATIVE TEIJIN PHARMA LTD (JP) 2020-08-05 — — EP disclosed
US-10689354-B2 Aminoazole derivative TEIJIN PHARMA LIMITED (JP) 2020-06-23 — — US disclosed
US-20190256513-A1 AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-08-22 — — US disclosed
US-20190031628-A1 AMINOAZOLE DERIVATIVE TEIJIN PHARMA LIMITED (JP) 2019-01-31 — — US disclosed
WO-2018166528-A1 PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS GENENTECH, INC. (US) 2018-09-20 — — WO disclosed
WO-2017099237-A1 AMINOAZOLE DERIVATIVE 帝人ファーマ株式会社 2017-06-15 — — WO disclosed
CN-101888999-B Pyridylmethyl-sulfonamide compounds BASF SE 2013-12-11 — — CN disclosed
EP-1860941-A1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF AKTIENGESELLSCHAFT (DE) 2007-12-05 — — EP disclosed
WO-2007036733-A1 PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS GLAXO GROUP LIMITED (GB) 2007-04-05 — — WO disclosed
WO-2007008140-A1 NEW PYRIDINE ANALOGUES ASTRAZENECA AB (SE) 2007-01-18 — — WO disclosed
US-20060293314-A1 4- Piridinylmethylsulphonamide derivatives as fungicidal plant protein agents BASF AKTIENGESELLSCHAFT (DE) 2006-12-28 — — US disclosed
CN-1852895-A 4-pyridinylmethyl sulfonamide derivatives as fungicidal plant protection agents BASF AG (DE) 2006-10-25 — — CN disclosed
CN-1852895-A 4-pyridinylmethyl sulfonamide derivatives as fungicidal plant protection agents BASF AG (DE) 2006-10-25 — — CN disclosed
WO-2006097488-A1 USE OF N- (4-PYRIDYL) METHYLSULFONAMIDES FOR COMBATING ARTHROPODAL PESTS BASF AKTIENGESELLSCHAFT (DE) 2006-09-21 — — WO disclosed
WO-2006097489-A1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF AKTIENGESELLSCHAFT (DE) 2006-09-21 — — WO disclosed
EP-1663976-A1 4-PYRIDINYLMETHYL SULFONAMIDE DERIVATIVES AS FUNGICIDAL PLANT PROTECTION AGENTS BASF AKTIENGESELLSCHAFT (DE) 2006-06-07 — — EP disclosed
WO-2005033081-A1 4-PIRIDINYLMETHYLSULPHONAMIDE DERIVATIVES AS FUNGICIDAL PLANT PROTECTION AGENTS BASF AKTIENGESELLSCHAFT (DE) 2005-04-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10689354-B2 Aminoazole derivative AR, NR3C2, NR5A1 CA2 1404/4885CA1 1484/4885CA5A 1711/4885
US-20190031628-A1 AMINOAZOLE DERIVATIVE AR, NR3C2, NR5A1 CA2 1404/4885CA1 1484/4885CA5A 1711/4885
US-10851098-B2 Azole amides and amines as alpha v integrin inhibitors ITGAV, ITGB1, ITGA1 CA2 1889/4885CA1 1863/4885CA5A 1628/4885
US-20190256513-A1 AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS ITGAV, ITGB1, ITGA1 CA2 1889/4885CA1 1863/4885CA5A 1628/4885
US-20060293314-A1 4- Piridinylmethylsulphonamide derivatives as fungicidal plant protein agents CBR3, CBR1, HEATR1 CA2 2317/4885CA1 4361/4885CA5A 4434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.