Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.47 |
| ▸ | TUBB | P07437 | 2/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3683983 | 0.85 | CA2 (0.54) | ACHETSHRAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL171116 | 0.83 | ACHE (1.00) | ACHEHTTTUBB1TUBB4ATUBB | |
| SCHEMBL19732198 | 0.82 | ACHE (0.52) | ACHETSHRHTTMAPTL3MBTL1 | |
| SCHEMBL14954539 | 0.79 | PTPN1 (0.55) | ACHETSHRAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL19732194 | 0.79 | ACHE (0.48) | ACHETSHRAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL1126364 | 0.79 | ACHE (0.52) | ACHEMAPTL3MBTL1KDM4ELMNA | |
| SCHEMBL5085895 | 0.79 | MAPT (0.51) | ACHETSHRAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL5236856 | 0.79 | TUBB1 (0.58) | ACHETSHRAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL19322018 | 0.78 | ACHE (0.47) | ACHETSHRAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL24086743 | 0.77 | CA2 (0.46) | ACHETSHRAPOBEC3AHTTAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816129-B2 | PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for treating type 2 diabetes mellitus | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2014-08-26 | — | — | US | claimed |
| US-20130131182-A1 | PTP1B INHIBITORS, SYNTHESIS THEREOF AND APPLICATION THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING TYPE 2 DIABETES MELLITUS | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2013-05-23 | — | — | US | claimed |
| US-8816129-B2 | PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for treating type 2 diabetes mellitus | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2014-08-26 | — | — | US | disclosed |
| US-8816129-B2 | PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for treating type 2 diabetes mellitus | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2014-08-26 | — | — | US | disclosed |
| US-8816129-B2 | PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for treating type 2 diabetes mellitus | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2014-08-26 | — | — | US | disclosed |
| US-8765994-B2 | Ship 1 modulators | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-07-01 | — | — | US | disclosed |
| US-8765994-B2 | Ship 1 modulators | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-07-01 | — | — | US | disclosed |
| US-20130131182-A1 | PTP1B INHIBITORS, SYNTHESIS THEREOF AND APPLICATION THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING TYPE 2 DIABETES MELLITUS | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2013-05-23 | — | — | US | disclosed |
| US-20130131182-A1 | PTP1B INHIBITORS, SYNTHESIS THEREOF AND APPLICATION THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING TYPE 2 DIABETES MELLITUS | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2013-05-23 | — | — | US | disclosed |
| US-20130131182-A1 | PTP1B INHIBITORS, SYNTHESIS THEREOF AND APPLICATION THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING TYPE 2 DIABETES MELLITUS | INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2013-05-23 | — | — | US | disclosed |
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2012-11-01 | — | — | US | disclosed |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-10-14 | — | — | US | disclosed |
| US-7737164-B2 | Cyanopyridine antibacterial agents | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-06-15 | — | — | US | disclosed |
| US-20080113994-A1 | Annelated Quinoline Derivatives As Pesticide | VELTEN ROBERT | 2008-05-15 | — | — | US | disclosed |
| US-20080113994-A1 | Annelated Quinoline Derivatives As Pesticide | VELTEN ROBERT | 2008-05-15 | — | — | US | disclosed |
| US-20080090909-A1 | negative regulator of cell growth factor receptor; pelorol (benzo(a)fluorene) related compounds from marine sponge species; antiinflammatory, antitumor agent, immunostimulant; control gene expression, differentiation, metabolism, phospholipid signaling pathway, signal tansduction | THE UNIVERSITY OF BRITISH COLUMBIA | 2008-04-17 | — | — | US | disclosed |
| US-20080090909-A1 | negative regulator of cell growth factor receptor; pelorol (benzo(a)fluorene) related compounds from marine sponge species; antiinflammatory, antitumor agent, immunostimulant; control gene expression, differentiation, metabolism, phospholipid signaling pathway, signal tansduction | THE UNIVERSITY OF BRITISH COLUMBIA | 2008-04-17 | — | — | US | disclosed |
| WO-2008016738-A2 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-02-07 | — | — | WO | disclosed |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-01-10 | — | — | US | disclosed |
| US-4419517-A | ANALGESICS | E. I. DU PONT DE NEMOURS & CO. (US) | 1983-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131182-A1 | PTP1B INHIBITORS, SYNTHESIS THEREOF AND APPLICATION THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING TYPE 2 DIABETES MELLITUS | PTPA, PPP2CA, PTPRS | ACHE 3901/4885TSHR 1075/4885APOBEC3A 4498/4885 |
| US-20080113994-A1 | Annelated Quinoline Derivatives As Pesticide | DDT, ACHE, SIRT4 | ACHE 2/4885TSHR 2903/4885APOBEC3A 2269/4885 |
| US-20120277252-A1 | Antibacterial Agents and Methods of Use Thereof | FDPS, ABCG2, DUT | ACHE 1665/4885TSHR 4271/4885APOBEC3A 1351/4885 |
| US-20080009528-A1 | ANTIBACTERIAL AGENTS AND RELATED SCREENING METHODS USING SMALL MOLECULE MACROARRAYS | PCNA, ABCG2, API5 | ACHE 3642/4885TSHR 4315/4885APOBEC3A 2359/4885 |
| US-20080090909-A1 | negative regulator of cell growth factor receptor; pelorol (benzo(a)fluorene) related compounds from marine sponge species; antiinflammatory, antitumor agent, immunostimulant; control gene expression, differentiation, metabolism, phospholipid signaling pathway, signal tansduction | STAT1, STING1, IRF3 | ACHE 4608/4885TSHR 880/4885APOBEC3A 4769/4885 |
| US-20100261763-A1 | ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF | FDPS, CYP3A5, ABCG2 | ACHE 1785/4885TSHR 4216/4885APOBEC3A 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.