Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.67 |
| ▸ | CTSS | P25774 | 6/20 | 0.67 |
| ▸ | CTSL | P07711 | 2/20 | 0.67 |
| ▸ | CTSB | P07858 | 1/20 | 0.67 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.65 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.43 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14104498 | 1.00 | CTSK (0.67) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL7302264 | 0.87 | CTSS (0.68) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL17449484 | 0.87 | CTSS (0.68) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL18941377 | 0.87 | CTSS (0.68) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL28969921 | 0.87 | CTSS (0.68) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL12201048 | 0.86 | CAPN1 (0.70) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL8693200 | 0.86 | CTSS (0.67) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL9787700 | 0.84 | CTSS (0.69) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL8694944 | 0.84 | CTSS (0.65) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL12653617 | 0.84 | CTSS (0.65) | CTSKCTSSCTSLCTSBCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142718-A1 | N-17-Alkylated Prodrugs of Opioids | SIGNATURE THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
| US-20120142718-A1 | N-17-Alkylated Prodrugs of Opioids | SIGNATURE THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
| US-20110105381-A2 | Prodrugs of Peripheral Phenolic Opioid Antagonists | PHARMACOFORE, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105381-A2 | Prodrugs of Peripheral Phenolic Opioid Antagonists | PHARMACOFORE, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20100267614-A1 | Prodrugs of Peripheral Phenolic Opioid Antagonists | PHARMACOFORE, INC. | 2010-10-21 | — | — | US | disclosed |
| US-20100267614-A1 | Prodrugs of Peripheral Phenolic Opioid Antagonists | PHARMACOFORE, INC. | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105381-A2 | Prodrugs of Peripheral Phenolic Opioid Antagonists | OPRM1, OPRL1, OPRK1 | CTSK 3149/4885CTSS 2476/4885CTSL 743/4885 |
| US-20120142718-A1 | N-17-Alkylated Prodrugs of Opioids | OPRM1, OPRD1, OPRL1 | CTSK 2485/4885CTSS 1792/4885CTSL 1675/4885 |
| US-20100267614-A1 | Prodrugs of Peripheral Phenolic Opioid Antagonists | OPRM1, OPRK1, OPRL1 | CTSK 3073/4885CTSS 2573/4885CTSL 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.