Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19479287 | 0.80 | KMT2A (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9AADK | |
| SCHEMBL17003300 | 0.78 | ALDH1A1 (0.40) | IKBKBCHUKALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL15667459 | 0.76 | SENP1 (0.54) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1001064 | 0.74 | ALOX15 (0.40) | IKBKBCHUKHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL999683 | 0.74 | MAPT (0.50) | IKBKBCHUKHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18929902 | 0.74 | EDNRB (0.39) | IKBKBCHUKHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL13454731 | 0.74 | ALDH1A1 (0.50) | IKBKBCHUKHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL26818554 | 0.73 | ADK (0.44) | SMN1; SMN2NPC1RAB9AADKMAPT | |
| SCHEMBL15696254 | 0.73 | PTGS2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTKDR | |
| SCHEMBL517237 | 0.73 | CYP2A6 (0.61) | IKBKBCHUKALDH1A1MAPK1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938244-B2 | Process for manufacturing pyrimidine sulfamide derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-04-10 | — | — | US | disclosed |
| US-20160368882-A1 | PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2016-12-22 | — | — | US | disclosed |
| US-8324232-B2 | 4-pyrimidinesulfamide derivative | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-12-04 | — | — | US | disclosed |
| US-20120142716-A1 | 4-PYRIMIDINESULFAMIDE DERIVATIVE | IDORSIA PHARMACEUTICALS LTD (CH) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368882-A1 | PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES | HAT1, SF1, SF3B5 | IKBKB 1622/4885CHUK 825/4885HTT 2192/4885 |
| US-20120142716-A1 | 4-PYRIMIDINESULFAMIDE DERIVATIVE | EDNRB, EDNRA, TBXA2R | IKBKB 1434/4885CHUK 266/4885HTT 3525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.