Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1527905 | 0.91 | MAPT (0.58) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL9894437 | 0.85 | MAPT (0.50) | NPC1RAB9AMAPTALDH1A1POLB | |
| SCHEMBL30672492 | 0.82 | MAPT (0.48) | MAPTALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL29288019 | 0.82 | MAPT (0.48) | MAPTALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL9895124 | 0.79 | G6PD (0.41) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL6558390 | 0.78 | NPC1 (0.46) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL16632740 | 0.76 | MAPT (0.52) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL29489592 | 0.76 | MAPT (0.52) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL454709 | 0.75 | ALDH1A1 (0.44) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL7173134 | 0.74 | LMNA (0.59) | NPC1RAB9AMAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260042765-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2026-02-12 | — | — | US | disclosed |
| US-12415809-B2 | Pyrrolotriazine compounds as tam inhibitors | INCYTE CORPORATION (US) | 2025-09-16 | — | — | US | disclosed |
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114456176-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-08-30 | — | — | CN | disclosed |
| US-20240124463-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2024-04-18 | — | — | US | disclosed |
| EP-4321513-A2 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | Incyte Corporation (US) | 2024-02-14 | — | — | EP | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| US-11591338-B2 | Pyrrolotriazine compounds as TAM inhibitors | INCYTE CORPORATION (US) | 2023-02-28 | — | — | US | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2017-09-28 | — | — | US | disclosed |
| US-9630928-B2 | Intermediates to prepare herbicidal pyrimidone derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-04-25 | — | — | US | disclosed |
| EP-2475654-B1 | HERBICIDAL PYRIMIDONE DERIVATIVES | DU PONT (US) | 2016-12-28 | — | — | EP | disclosed |
| US-20160024020-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | FMC CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-9187432-B2 | Intermediates to prepare herbicidal pyrimidone derivatives | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150105549-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | FMC CORPORATION | 2015-04-16 | — | — | US | disclosed |
| US-8952024-B2 | Herbicidal pyrimidone derivatives | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-02-10 | — | — | US | disclosed |
| CN-102596933-B | Herbicidal pyrimidone derivatives | DU PONT | 2014-09-17 | — | — | CN | disclosed |
| US-20120149573-A1 | HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | FMC CORPORATION | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260042765-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MAP2K2, TTK, MAP2K5 | NPC1 4002/4885RAB9A 1162/4885MAPT 3577/4885 |
| US-20120149573-A1 | HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | CBR3, CYP1B1, CBR1 | NPC1 3841/4885RAB9A 2193/4885MAPT 4805/4885 |
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | NPC1 3819/4885RAB9A 2040/4885MAPT 3032/4885 |
| US-20150105549-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | CBR3, CBR1, MSRB3 | NPC1 4667/4885RAB9A 2164/4885MAPT 4761/4885 |
| US-12415809-B2 | Pyrrolotriazine compounds as tam inhibitors | MERTK, MAP3K15, MAP3K5 | NPC1 3819/4885RAB9A 2040/4885MAPT 3032/4885 |
| US-11591338-B2 | Pyrrolotriazine compounds as TAM inhibitors | MERTK, MAP3K15, MAP3K5 | NPC1 3819/4885RAB9A 2040/4885MAPT 3032/4885 |
| US-20160024020-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | CBR3, CBR1, PNPO | NPC1 4644/4885RAB9A 2039/4885MAPT 4753/4885 |
| US-20240124463-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | NPC1 3819/4885RAB9A 2040/4885MAPT 3032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.