Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | RPA1 | P27694 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | FRK | P42685 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464496 | 0.76 | MAPK1 (0.40) | MAPK14MAPK9MAPK11MAPK13MAPK12 | |
| SCHEMBL25220966 | 0.71 | MAPK14 (0.57) | MAPK14MAPK9MAPK11MAPK13MAPK12 | |
| SCHEMBL6626583 | 0.71 | MAPK14 (0.57) | MAPK14MAPK9MAPK11MAPK13MAPK12 | |
| SCHEMBL28327757 | 0.71 | MAPK14 (0.49) | MAPK14MAPK9MAPK11MAPK13MAPK12 | |
| SCHEMBL9894870 | 0.71 | MAPK14 (0.40) | MAPK14MAPK9MAPK11MAPK13MAPK12 | |
| SCHEMBL5387186 | 0.70 | CSNK1D (0.45) | MAPK9ALDH1A1SMN1; SMN2PRKD3MAP4K4 | |
| SCHEMBL1384144 | 0.68 | SCN4A (0.53) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28327758 | 0.68 | PTGS1 (0.42) | MAPK14MAPK9MAPK11MAPK13MAPK12 | |
| SCHEMBL2471849 | 0.67 | PTGS2 (0.51) | MAPK14MAPK9MAPK11BRD4CSNK1D | |
| SCHEMBL23294592 | 0.67 | ALPL (0.33) | CA12ALPLRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466181-B2 | 1,2,3-triazole-imidazole compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-18 | — | — | US | disclosed |
| US-20120149675-A1 | 1,2,3-TRIAZOLE-IMIDAZOLECOMPOUNDS | HOFFMANN-LA ROCHE INC. | 2012-06-14 | — | — | US | disclosed |
| US-20120145241-A1 | PHOTOVOLTAIC MODULE WITH STABILIZED POLYMERIC ENCAPSULANT | BASF SE (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149675-A1 | 1,2,3-TRIAZOLE-IMIDAZOLECOMPOUNDS | GABRA5, GABRA1, GABRB1 | MAPK14 4554/4885MAPK9 4059/4885MAPK11 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.