Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899175 | 0.90 | SMN1; SMN2 (0.47) | PLA2G2AMAPK8CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9898507 | 0.87 | NR4A2 (0.50) | MAPK8KDM4ENR4A2EGFRALDH1A1 | |
| SCHEMBL6170807 | 0.84 | LMNA (0.50) | MAPK8KDM4ENR4A2EGFRALDH1A1 | |
| SCHEMBL9899615 | 0.83 | PLA2G2A (0.49) | PLA2G2AMAPK8CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30128969 | 0.82 | DHODH (0.46) | PLA2G2AKDM4ENR4A2EGFRALDH1A1 | |
| SCHEMBL17733182 | 0.82 | FABP3 (0.47) | PLA2G2AMAPK8CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1334120 | 0.82 | DHODH (0.46) | PLA2G2AKDM4ENR4A2EGFRALDH1A1 | |
| SCHEMBL6169484 | 0.80 | PLA2G2A (0.43) | PLA2G2AMAPK8GABRA1GABRG2GABRB3 | |
| SCHEMBL1514525 | 0.80 | GPR35 (0.50) | KDM4EALDH1A1LMNAHPGDDHODH | |
| SCHEMBL8510685 | 0.78 | PLA2G2A (0.51) | PLA2G2AMAPK8CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9028728-B2 | Photochromic materials that include indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2013086248-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 2013-06-13 | — | — | WO | disclosed |
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | TRANSITIONS OPTICAL INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | NQO1, INTS6, IPO4 | PLA2G2A 1829/4885MAPK8 2332/4885CYP1A2 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.