Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA3 | P07451 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA6 | P23280 | 2/20 | 0.31 |
| ▸ | CA5A | P35218 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL7621993 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL371424 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL220600 | 1.00 | — | — | |
| Ethylenediamine SCHEMBL10703973 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL3410087 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL19066603 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL987205 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL4077816 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL8667785 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL642828 | 1.00 | NFKB1 (0.33) | NFKB1TSHRCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006011-A2 | THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES | VIRGINIA TECH INTELLECTUAL PROPERTIES INC. (US) | 2011-01-13 | — | — | WO | claimed |
| US-20110009478-A1 | THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2011-01-13 | — | — | US | claimed |
| WO-2023167184-A1 | NEUTROPHIL DEPLETING MATERIAL AND METHOD FOR PRODUCING NEUTROPHIL DEPLETING MATERIAL | 東レ株式会社 | 2023-09-07 | — | — | WO | disclosed |
| CN-109562219-B | Material for purifying blood | 东丽株式会社 | 2021-05-18 | — | — | CN | disclosed |
| EP-3513821-B1 | MATERIAL FOR BLOOD PURIFICATION | TORAY INDUSTRIES (JP) | 2020-08-19 | — | — | EP | disclosed |
| US-10646850-B2 | Material for blood purification | TORAY INDUSTRIES, INC. (JP) | 2020-05-12 | — | — | US | disclosed |
| EP-3513821-A1 | MATERIAL FOR BLOOD PURIFICATION | Toray Industries, Inc. (JP) | 2019-07-24 | — | — | EP | disclosed |
| US-20190184371-A1 | MATERIAL FOR BLOOD PURIFICATION | TORAY INDUSTRIES, INC. (JP) | 2019-06-20 | — | — | US | disclosed |
| WO-2011006011-A2 | THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES | VIRGINIA TECH INTELLECTUAL PROPERTIES INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| US-20110009478-A1 | THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2011-01-13 | — | — | US | disclosed |
| US-20110009478-A1 | THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2011-01-13 | — | — | US | disclosed |
| US-4673729-A | Paper auxiliary from condensation product of aliphatic polyol-ether-amine and compound polyfunctional toward amino groups | BAYER AKTIENGESELLSCHAFT (DE) | 1987-06-16 | — | — | US | disclosed |
| US-4384110-A | POLYALKYLENE-AMINES, PAPERMAKING | BAYER AKTIENGESELLSCHAFT (DE) | 1983-05-17 | — | — | US | disclosed |
| US-4348514-A | ACCELERATION OF DRAINAGE IN PAPERMAKING | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | disclosed |
| US-4319019-A | RETENTION AIDS AND DRAINAGE ACCELERATORS IN PAPERMAKING | BAYER AKTIENGESELLSCHAFT (DE) | 1982-03-09 | — | — | US | disclosed |
| EP-0005241-B1 | POLYALKYLENE POLYAMINES CONTAINING QUATERNARY AMMONIUM GROUPS, METHOD FOR THEIR PREPARATION AND THEIR USE AS AUXILIARY AGENTS IN PAPER MAKING | BAYER AG (DE) | 1981-04-01 | — | — | EP | disclosed |
| US-4250112-A | PAPERMAKING | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-10 | — | — | US | disclosed |
| US-4250298-A | RETENTION AGENTS AND DRAINAGE ACCELERATORS FOR PAPERMAKING | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-10 | — | — | US | disclosed |
| US-4250299-A | RETENTION AGENTS AND DRAINAGE ACCELERATORS FOR PAPERMAKING | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009478-A1 | THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES | TRDMT1, LGALS3, ELAVL1 | NFKB1 1927/4885TSHR 879/4885CA12 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.