Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.56 |
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.56 |
| ▸ | HNF4A | P41235 | 2/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1009517 | 0.96 | THRB (0.65) | THRBMCL1ACMSDHNF4ADHFR | |
| SCHEMBL1711104 | 0.89 | THRB (0.56) | THRBMCL1ACMSDHNF4ADHFR | |
| SCHEMBL10418680 | 0.84 | THRB (0.53) | THRBMCL1ACMSDHNF4ADHFR | |
| SCHEMBL9898507 | 0.83 | NR4A2 (0.50) | THRBMCL1KDM4EMEN1NSD2 | |
| SCHEMBL9899175 | 0.81 | SMN1; SMN2 (0.47) | THRBMCL1ACMSDHNF4ADHFR | |
| SCHEMBL17736804 | 0.81 | ALDH1A1 (0.54) | THRBMCL1ACMSDHNF4ADHFR | |
| SCHEMBL1010666 | 0.81 | ACMSD (0.46) | THRBMCL1ACMSDHNF4ADHFR | |
| SCHEMBL6202371 | 0.79 | THRB (0.49) | THRBKDM4EMEN1MAPTKMT2A | |
| SCHEMBL6170807 | 0.79 | LMNA (0.50) | THRBMCL1KDM4EMEN1NSD2 | |
| SCHEMBL17733182 | 0.77 | FABP3 (0.47) | THRBKDM4EMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9028728-B2 | Photochromic materials that include indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | TRANSITIONS OPTICAL INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | NQO1, INTS6, IPO4 | THRB 4763/4885MCL1 3938/4885ACMSD 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.