Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907399 | 0.86 | ALOX15 (0.46) | GRM2HDAC1KDM1AHDAC2HDAC11 | |
| SCHEMBL9907472 | 0.86 | HTR5A (0.44) | KDM4CIP6K1IP6K3IP6K2MEN1 | |
| SCHEMBL9907352 | 0.85 | KMO (0.51) | GRM2KDM4CKDM5AKDM5BMRGPRX4 | |
| SCHEMBL9907816 | 0.83 | HTR5A (0.53) | GRM2 | |
| SCHEMBL9909211 | 0.82 | PTGDR2 (0.45) | KDM4CIP6K1IP6K3IP6K2PTGDR2 | |
| SCHEMBL9907492 | 0.81 | PTGDR2 (0.42) | JAK2GRM2HDAC1KDM1AHDAC2 | |
| SCHEMBL9907370 | 0.80 | MAPKAPK2 (0.40) | KDM4CKDM5AKDM5BPOLBMRGPRX4 | |
| SCHEMBL9907412 | 0.79 | KMO (0.50) | KDM5AKDM5BIP6K1IP6K3IP6K2 | |
| SCHEMBL9907394 | 0.79 | CSNK2A2 (0.43) | KDM4CKDM5AKDM5BIP6K1IP6K3 | |
| SCHEMBL9907411 | 0.79 | MPL (0.45) | IP6K1IP6K3IP6K2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | JAK2 4583/4885GRM2 109/4885HDAC1 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.