Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | IL1B | P01584 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907411 | 0.90 | MPL (0.45) | KMOIP6K1IP6K3IP6K2MEN1 | |
| SCHEMBL9907409 | 0.87 | ALOX15 (0.45) | KMOTLR8KDM4EALDH1A1GAA | |
| SCHEMBL9907820 | 0.84 | HTR5A (0.53) | KMO | |
| SCHEMBL9909220 | 0.83 | KIF11 (0.50) | KMOIP6K1IP6K3IP6K2CAMKK1 | |
| SCHEMBL9909223 | 0.81 | KMO (0.52) | KMOIP6K1IP6K3IP6K2CAMKK1 | |
| SCHEMBL9907472 | 0.80 | HTR5A (0.44) | IP6K1IP6K3IP6K2MEN1NPC1 | |
| SCHEMBL9907403 | 0.79 | JAK2 (0.45) | IP6K1IP6K3IP6K2MEN1NPC1 | |
| SCHEMBL9907326 | 0.78 | PIK3CA (0.57) | IP6K1IP6K3IP6K2MEN1NPC1 | |
| SCHEMBL9907394 | 0.78 | CSNK2A2 (0.43) | IP6K1IP6K3IP6K2MEN1NPC1 | |
| SCHEMBL9907408 | 0.77 | ALOX15 (0.45) | TLR8KDM4EALDH1A1GAAPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | KMO 559/4885AKR1C3 1605/4885AKR1C2 1483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.