Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | PKN1 | Q16512 | 5/20 | 0.66 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.66 |
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | MMP9 | P14780 | 1/20 | 0.61 |
| ▸ | MMP8 | P22894 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.59 |
| ▸ | SCD | O00767 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13599850 | 0.90 | NPC1 (0.81) | NPC1RAB9AMMP2MMP9MMP8 | |
| SCHEMBL13183701 | 0.88 | NPC1 (0.78) | NPC1RAB9AMMP2MMP9MMP8 | |
| SCHEMBL20677813 | 0.86 | NPC1 (0.75) | NPC1RAB9AMMP2MMP9MMP8 | |
| SCHEMBL276208 | 0.85 | NPC1 (0.73) | NPC1RAB9AMMP2MMP9MMP8 | |
| SCHEMBL29899998 | 0.85 | NPC1 (0.73) | NPC1RAB9AMMP2MMP9MMP8 | |
| Ridinilazole SCHEMBL29613225 | 0.84 | NPC1 (0.73) | NPC1RAB9APKN1PKN2KDM4E | |
| Ridinilazole SCHEMBL29785777 | 0.84 | NPC1 (0.73) | NPC1RAB9APKN1PKN2KDM4E | |
| Ridinilazole SCHEMBL19235713 | 0.84 | NPC1 (0.73) | NPC1RAB9APKN1PKN2KDM4E | |
| SCHEMBL6124301 | 0.83 | NPC1 (0.71) | NPC1RAB9AMMP2MMP9MMP8 | |
| SCHEMBL7388571 | 0.82 | NPC1 (0.69) | NPC1RAB9AMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249106-B2 | Substituted hydrazide compounds and use thereof | SHENYANG J & HEALTH PHARMACEUTICAL CO., LTD. (CN) | 2016-02-02 | — | — | US | disclosed |
| EP-2468730-A1 | SUBSTITUTED HYDRAZIDE COMPOUNDS AND APPLICATION THEREOF | Shenyang J & Health Pharmaceutical Co., Ltd. (CN) | 2012-06-27 | — | — | EP | disclosed |
| US-20120142921-A1 | SUBSTITUTED HYDRAZIDE COMPOUNDS AND USE THEREOF | SHENYANG J & HEALTH PHARMACEUTICAL CO., LTD. (CN) | 2012-06-07 | — | — | US | disclosed |
| US-20090029990-A1 | Dihydropteridinones in the treatment of respiratory diseases | MAIER UDO | 2009-01-29 | — | — | US | disclosed |
| US-20070043055-A1 | Dihydropteridinones in the treatment of respiratory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142921-A1 | SUBSTITUTED HYDRAZIDE COMPOUNDS AND USE THEREOF | SLC5A1, VHL, AKR1A1 | NPC1 1110/4885RAB9A 1283/4885PKN1 1356/4885 |
| US-20070043055-A1 | Dihydropteridinones in the treatment of respiratory diseases | QDPR, DHPS, NDUFS6 | NPC1 1844/4885RAB9A 2056/4885PKN1 2617/4885 |
| US-20090029990-A1 | Dihydropteridinones in the treatment of respiratory diseases | QDPR, DHPS, NDUFS6 | NPC1 1844/4885RAB9A 2056/4885PKN1 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.