Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 9/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915467 | 0.88 | TRPC6 (0.48) | TRPC6ALDH1A1HPGD | |
| SCHEMBL14124857 | 0.79 | TRPC6 (0.52) | TRPC6S1PR1S1PR5 | |
| SCHEMBL9915449 | 0.79 | S1PR1 (0.55) | S1PR1S1PR5S1PR3 | |
| SCHEMBL9915360 | 0.78 | KDM4E (0.47) | ALDH1A1HPGD | |
| SCHEMBL9915365 | 0.77 | MAPT (0.44) | TRPC6ALDH1A1HPGD | |
| SCHEMBL9915498 | 0.74 | KDM4E (0.44) | TRPC6ALDH1A1HPGD | |
| SCHEMBL9915414 | 0.73 | TSHR (0.54) | ALDH1A1HPGD | |
| SCHEMBL9915408 | 0.70 | EGLN1 (0.45) | ALDH1A1HPGD | |
| SCHEMBL9915460 | 0.68 | CYP1A2 (0.38) | TRPC6ALDH1A1HPGD | |
| SCHEMBL9915472 | 0.68 | BACE1 (0.41) | TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | TRPC6 1175/4885S1PR1 3300/4885S1PR5 2362/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | TRPC6 1175/4885S1PR1 3300/4885S1PR5 2362/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | TRPC6 1175/4885S1PR1 3300/4885S1PR5 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.