Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SELL | P14151 | 1/20 | 0.31 |
| ▸ | SELP | P16109 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683495 | 0.83 | ALDH1A1 (0.37) | HCAR2TSHRACHEKDM4EALDH1A1 | |
| SCHEMBL8251832 | 0.74 | GPR84 (0.30) | HCAR2 | |
| SCHEMBL9915412 | 0.74 | TRPA1 (0.36) | TRPA1SELLSELPSELEACHE | |
| SCHEMBL5763802 | 0.73 | GPR35 (0.46) | TSHRKDM4EALDH1A1MAPT | |
| SCHEMBL14124845 | 0.72 | TRPA1 (0.35) | TRPA1SELLSELPSELEACHE | |
| SCHEMBL15680568 | 0.67 | ALOX15 (0.33) | TRPA1 | |
| SCHEMBL5944839 | 0.65 | PDE10A (0.40) | TSHRACHEKDM4EALDH1A1MAPT | |
| SCHEMBL6364147 | 0.65 | CYP3A4 (0.33) | HCAR2TSHR | |
| SCHEMBL1314444 | 0.63 | CD44 (0.36) | HCAR2TSHR | |
| SCHEMBL19554522 | 0.63 | HCAR2 (0.31) | HCAR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014068388-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2014-05-08 | — | — | WO | disclosed |
| EP-2703406-A1 | NOVEL CEPHEM COMPOUND HAVING CATECHOL OR PSEUDO-CATECHOL STRUCTURE | Shionogi & Co., Ltd. (JP) | 2014-03-05 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | HCAR2 615/4885TRPA1 2014/4885TSHR 4478/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | HCAR2 615/4885TRPA1 2014/4885TSHR 4478/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | HCAR2 615/4885TRPA1 2014/4885TSHR 4478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.