Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 15/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915465 | 0.88 | TRPC6 (0.47) | TRPC6ALDH1A1HPGD | |
| SCHEMBL14124829 | 0.81 | TRPC6 (0.54) | TRPC6NPC1RAB9ACSF1R | |
| SCHEMBL9915450 | 0.80 | S1PR1 (0.42) | TRPC6NPC1RAB9A | |
| SCHEMBL9915365 | 0.75 | MAPT (0.44) | TRPC6ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9915360 | 0.73 | KDM4E (0.47) | ALDH1A1HPGD | |
| SCHEMBL9915498 | 0.72 | KDM4E (0.44) | TRPC6ALDH1A1HPGDCNR2 | |
| SCHEMBL9915414 | 0.71 | TSHR (0.54) | ALDH1A1HPGDRAB9A | |
| SCHEMBL27682598 | 0.69 | SMN1; SMN2 (0.50) | ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9915408 | 0.69 | EGLN1 (0.45) | ALDH1A1HPGD | |
| SCHEMBL9915496 | 0.68 | MAOB (0.48) | ALDH1A1HPGDNPC1RAB9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | TRPC6 1175/4885ALDH1A1 1829/4885HPGD 2345/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | TRPC6 1175/4885ALDH1A1 1829/4885HPGD 2345/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | TRPC6 1175/4885ALDH1A1 1829/4885HPGD 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.