Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219713 | 0.85 | ALDH1A1 (0.48) | RAB9ACYP2C9ALDH1A1NPC1LMNA | |
| SCHEMBL10850521 | 0.84 | RAB9A (0.47) | RAB9ACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13765185 | 0.84 | ELANE (0.46) | CYP3A4CYP2D6CYP2C9ALDH1A1LMNA | |
| SCHEMBL13790082 | 0.81 | ELANE (0.41) | CYP2C9ALDH1A1MAPTELANE | |
| SCHEMBL13765196 | 0.81 | ELANE (0.41) | CYP2C9ALDH1A1MAPTELANE | |
| SCHEMBL4218555 | 0.77 | CTRB1 (0.46) | RAB9ACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23440237 | 0.77 | TP53 (0.53) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL15991784 | 0.76 | POLB (0.43) | ALDH1A1NPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL13765035 | 0.75 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2ELANEGAA | |
| SCHEMBL15446321 | 0.75 | ALDH1A1 (0.48) | RAB9ACYP2C9ALDH1A1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | RAB9A 2614/4885CYP3A4 929/4885CYP2D6 353/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | RAB9A 2614/4885CYP3A4 929/4885CYP2D6 353/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | RAB9A 2614/4885CYP3A4 929/4885CYP2D6 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.