SCHEMBL9917150

SCHEMBL9917150

Cc1nc(Cl)nc(NC(C)(C)CC(C)(C)C)n1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
PDE4A P27815 5/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.40
NPC1 O15118 2/20 0.37
GAA P10253 2/20 0.36
RAB9A P51151 1/20 0.35
PIK3CA P42336 1/20 0.31
MAPT P10636 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7870541 0.89 LMNA (0.59) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL39222 0.89 LMNA (0.54) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL13588261 0.87 NPSR1 (0.33) LMNASMN1; SMN2KMT2AMAPTNPSR1
SCHEMBL22159266 0.82 LMNA (0.47) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL13270943 0.79 LMNA (0.44) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL4303475 0.78 SMN1; SMN2 (0.41) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL10444894 0.74 LMNA (0.37) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL10522528 0.71 CRHR1 (0.37) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL10522655 0.71 LMNA (0.37) LMNASMN1; SMN2PDE4ACYP1A2CYP2C19
SCHEMBL5671532 0.71 MEN1 (0.36) LMNASMN1; SMN2KMT2AGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9546261-B2 Stabilizing of organic material with amino-triazine based mannich-compounds BOREALIS AG (AT) 2017-01-17 US disclosed
US-9546261-B2 Stabilizing of organic material with amino-triazine based mannich-compounds BOREALIS AG (AT) 2017-01-17 US disclosed
US-20140235766-A1 Stabilizing of Organic Material with Amino-Triazine Based Mannich-Compounds BOREALIS AG (AT) 2014-08-21 US disclosed
US-20140235766-A1 Stabilizing of Organic Material with Amino-Triazine Based Mannich-Compounds BOREALIS AG (AT) 2014-08-21 US disclosed
US-20120145236-A1 UV-STABILIZED PHOTOVOLTAIC MODULE BASF SE (DE) 2012-06-14 US disclosed
US-20120145236-A1 UV-STABILIZED PHOTOVOLTAIC MODULE BASF SE (DE) 2012-06-14 US disclosed
US-20100178484-A1 TRANSPARENT POLYMER ARTICLES OF LOW THICKNESS LEPPARD DAVID GEORGE 2010-07-15 US disclosed
US-20090312464-A1 Stabilizer mixtures GUGUMUS FRANCOIS 2009-12-17 US disclosed
US-20090291289-A1 TRANSPARENT POLYMER ARTICLES OF LOW THICKNESS LEPPARD DAVID GEORGE 2009-11-26 US disclosed
US-20090291289-A1 TRANSPARENT POLYMER ARTICLES OF LOW THICKNESS LEPPARD DAVID GEORGE 2009-11-26 US disclosed
US-20090042006-A1 Transparent polymer articles of low thickness LEPPARD DAVID GEORGE 2009-02-12 US disclosed
US-7332105-B2 Synergistic UV absorber combination CIBA SPECIALTY CHEMICALS CORPORATION (US) 2008-02-19 US disclosed
US-20070259165-A1 Transparent polymer articles of low thickness LEPPARD DAVID G 2007-11-08 US disclosed
US-20070259165-A1 Transparent polymer articles of low thickness LEPPARD DAVID G 2007-11-08 US disclosed
US-7265171-B2 Transparent polymer articles of low thickness CIBA SPECIALTY CHEMICALS CORP. (US) 2007-09-04 US disclosed
US-7265171-B2 Transparent polymer articles of low thickness CIBA SPECIALTY CHEMICALS CORP. (US) 2007-09-04 US disclosed
US-7169835-B2 Stabilizer mixture CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-01-30 US disclosed
US-7169835-B2 Stabilizer mixture CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-01-30 US disclosed
US-7166653-B2 Transparent polymer articles of low thickness CIBA SPECIALTY CHEMICALS CORP. (US) 2007-01-23 US disclosed
US-7166653-B2 Transparent polymer articles of low thickness CIBA SPECIALTY CHEMICALS CORP. (US) 2007-01-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140235766-A1 Stabilizing of Organic Material with Amino-Triazine Based Mannich-Compounds PCNA, SOD1, UBE2M LMNA 467/4885SMN1; SMN2 2197/4885PDE4A 4861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.