Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9914296 | 0.81 | GRIN1 (0.65) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL510762 | 0.81 | GRIN1 (0.65) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL12132159 | 0.81 | GRIN1 (0.65) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL12130587 | 0.81 | GRIN1 (0.65) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL8720366 | 0.81 | GRIN1 (0.65) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL1880961 | 0.78 | LMNA (0.67) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| Water SCHEMBL28015899 | 0.78 | GRIN1 (0.61) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL866896 | 0.78 | LMNA (0.67) | PKMGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL480287 | 0.74 | GRIN2D (0.53) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL1362423 | 0.74 | PKM (0.56) | PKMGRIN1GRIN2AGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252741-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-10-04 | — | — | US | claimed |
| US-20120129763-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-05-24 | — | — | US | claimed |
| WO-2011140009-A1 | METHODS OF USING SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | BIOMARIN PHARMACEUTICAL INC. (US) | 2011-11-10 | — | — | WO | claimed |
| EP-2373694-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | BioMarin Pharmaceutical Inc. (US) | 2011-10-12 | — | — | EP | claimed |
| US-20110015119-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | LEAD THERAPEUTICS, INC. (US) | 2011-01-20 | — | — | US | claimed |
| EP-2238102-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | Lead Therapeutics, Inc. (US) | 2010-10-13 | — | — | EP | claimed |
| US-20100216699-A1 | SEMI-SYNTHETIC GLYCOPEPTIDES HAVING ANTIBACTERIAL ACTIVITY | LEAD THERAPEUTICS, INC. (US) | 2010-08-26 | — | — | US | claimed |
| WO-2010065174-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | LEAD THERAPEUTICS, INC. (US) | 2010-06-10 | — | — | WO | claimed |
| WO-2010048340-A2 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | LEAD THERAPEUTICS, INC. (US) | 2010-04-29 | — | — | WO | claimed |
| US-20100105607-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | LEAD THERAPEUTICS, INC. (US) | 2010-04-29 | — | — | US | claimed |
| US-20080214444-A1 | SEMI-SYNTHETIC REARRANGED VANCOMYCIN/DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | US | claimed |
| EP-1868630-A2 | SEMI-SYNTHETIC DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | Novartis Vaccines and Diagnostics, Inc. (US) | 2007-12-26 | — | — | EP | claimed |
| EP-1861115-A2 | SEMI-SYNTHETIC GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | Novartis Vaccines and Diagnostics, Inc. (US) | 2007-12-05 | — | — | EP | claimed |
| EP-1858908-A2 | SEMI-SYNTHETIC REARRANGED VANCOMYCIN/DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | Novartis Vaccines and Diagnostics, Inc. (US) | 2007-11-28 | — | — | EP | claimed |
| US-20070185015-A1 | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity | Chiron Corporation and North China Pharmaceutical Corporation | 2007-08-09 | — | — | US | claimed |
| US-20070021328-A1 | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity | CHIRON CORPORATION | 2007-01-25 | — | — | US | claimed |
| US-20060276623-A1 | Semi-synthetic glycopeptides with antibiotic activity | CHIRON CORPORATION | 2006-12-07 | — | — | US | claimed |
| WO-2006093933-A2 | SEMI-SYNTHETIC REARRANGED VANCOMYCIN/DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2006-09-08 | — | — | WO | claimed |
| WO-2006093947-A2 | SEMI-SYNTHETIC GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2006-09-08 | — | — | WO | claimed |
| WO-2006094082-A2 | SEMI-SYNTHETIC DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2006-09-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216699-A1 | SEMI-SYNTHETIC GLYCOPEPTIDES HAVING ANTIBACTERIAL ACTIVITY | ASNS, ALG1, ALG8 | PKM 3239/4885GRIN1 1235/4885GRIN2A 1097/4885 |
| US-20100105607-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | ASNS, ALG8, ALG1 | PKM 3059/4885GRIN1 1036/4885GRIN2A 1046/4885 |
| US-20070185015-A1 | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity | AADAC, DNPEP, STT3A | PKM 1558/4885GRIN1 1470/4885GRIN2A 1900/4885 |
| US-20060276623-A1 | Semi-synthetic glycopeptides with antibiotic activity | FUT6, AAAS, O60361 | PKM 994/4885GRIN1 1674/4885GRIN2A 1736/4885 |
| US-20070021328-A1 | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity | DNPEP, ASNS, SI | PKM 1432/4885GRIN1 1222/4885GRIN2A 1728/4885 |
| US-20120129763-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | ASNS, SI, DNPEP | PKM 1564/4885GRIN1 1160/4885GRIN2A 1868/4885 |
| US-20080214444-A1 | SEMI-SYNTHETIC REARRANGED VANCOMYCIN/DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY | DNPEP, ASNS, SI | PKM 1432/4885GRIN1 1222/4885GRIN2A 1728/4885 |
| US-20120252741-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | ASNS, DNPEP, ALG8 | PKM 2848/4885GRIN1 1326/4885GRIN2A 1251/4885 |
| US-20110015119-A1 | NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS | SI, FUT6, B3GAT3 | PKM 2450/4885GRIN1 1174/4885GRIN2A 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.