Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | CASP7 | P55210 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9925972 | 0.82 | KDM4E (0.54) | ALDH1A1MAPTHTTCYP3A4CYP2C9 | |
| SCHEMBL4084506 | 0.73 | ALDH1A1 (0.67) | ALDH1A1MAPTHTTMEN1KMT2A | |
| SCHEMBL20988857 | 0.65 | LMNA (0.55) | ALDH1A1MAPTHTTCYP3A4CYP2C9 | |
| SCHEMBL9925966 | 0.65 | ABCC9 (0.48) | ALDH1A1MAPTKMT2ANPSR1KDM4E | |
| SCHEMBL9925969 | 0.65 | KDM4E (0.68) | ALDH1A1MAPTNPSR1KDM4EPOLB | |
| SCHEMBL12001639 | 0.64 | KDM4E (0.55) | ALDH1A1MAPTHTTMEN1KMT2A | |
| SCHEMBL562770 | 0.64 | ALDH1A1 (0.68) | ALDH1A1MAPTHTTCYP3A4CYP2C9 | |
| SCHEMBL3129599 | 0.64 | ALDH1A1 (0.72) | ALDH1A1MAPTHTTCYP3A4CYP2C9 | |
| SCHEMBL6706684 | 0.63 | ALDH1A1 (0.79) | ALDH1A1MAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11998882 | 0.63 | KDM4E (0.60) | ALDH1A1MAPTHTTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078902-A2 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |