Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 7/20 | 0.35 |
| ▸ | PGR | P06401 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940214 | 0.85 | MAOA (0.31) | — | |
| SCHEMBL9933463 | 0.81 | PDK2 (0.34) | PDK2MEN1KMT2AHTR1AHTR2A | |
| SCHEMBL16713272 | 0.80 | KDM4E (0.35) | PDK2KDM4E | |
| SCHEMBL9932470 | 0.79 | PGR (0.33) | PDK2PGRMEN1KMT2ACHRM2 | |
| SCHEMBL9934120 | 0.78 | PDK2 (0.40) | PDK2PGRMLNRNR1I2CHRM2 | |
| SCHEMBL164745 | 0.76 | LMNA (0.39) | PDK2MEN1KMT2AMLNRNR1I2 | |
| SCHEMBL29664335 | 0.76 | ESR1 (0.33) | PDK2MLNRNR1I2CHRM2ADRB1 | |
| SCHEMBL9929735 | 0.76 | ESR1 (0.33) | PDK2MLNRNR1I2CHRM2ADRB1 | |
| SCHEMBL9971715 | 0.72 | PPARG (0.44) | PDK2MEN1KMT2AKDM4EESR1 | |
| SCHEMBL720632 | 0.70 | PDK2 (0.38) | PDK2PGRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073838-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073838-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073838-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | TRANSITIONS OPTICALS, INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | TRANSITIONS OPTICALS, INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | TRANSITIONS OPTICALS, INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-8765978-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2012082837-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012082837-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | IDH3A, NQO1, IDH3B | PDK2 714/4885PGR 128/4885MEN1 595/4885 |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | NQO1, IDH3A, IDH2 | PDK2 559/4885PGR 263/4885MEN1 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.