Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1815176 | 0.90 | PGR (0.34) | PDK2PGRGCGRCA6CA1 | |
| SCHEMBL2630542 | 0.84 | RAB9A (0.40) | PDK2LMNAHTTTRPM4KDM4E | |
| SCHEMBL164745 | 0.83 | LMNA (0.39) | PDK2LMNAHTTTRPM4KDM4E | |
| SCHEMBL160603 | 0.82 | PDK2 (0.37) | PDK2LMNAHTTTRPM4CA6 | |
| SCHEMBL161727 | 0.81 | ALOX5 (0.39) | PDK2LMNAHTTPGRKDM4E | |
| SCHEMBL12859979 | 0.81 | HTT (0.45) | LMNAHTTTRPM4CA1KDM4E | |
| SCHEMBL18352309 | 0.80 | TRPM4 (0.39) | LMNAHTTTRPM4CA1KDM4E | |
| SCHEMBL10010822 | 0.80 | ACHE (0.35) | PDK2PGRCA6CA1CA2 | |
| SCHEMBL10009838 | 0.79 | ACHE (0.38) | PDK2HTTCA6CA1CA2 | |
| SCHEMBL10010882 | 0.79 | ACHE (0.35) | PDK2PGRCA6CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345647-A2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | claimed |
| US-7557208-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | claimed |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2009-03-05 | — | — | US | claimed |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-07-05 | — | — | US | claimed |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | claimed |
| EP-1606274-B9 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-1606274-B1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2018-08-08 | — | — | EP | disclosed |
| US-8535577-B2 | Photochromic materials that include 6-amino substituted indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| EP-2345648-B1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL INC (US) | 2012-10-24 | — | — | EP | disclosed |
| US-8277699-B2 | Photochromic materials that include 6-amino substituted indeno-fused naphthopyrans | Transistions Optical, Inc. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120214992-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2012-08-23 | — | — | US | disclosed |
| US-20120053341-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2012-03-01 | — | — | US | disclosed |
| EP-2345647-A2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2345648-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7557208-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7517982-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-7262295-B2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-07-05 | — | — | US | disclosed |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214992-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | NPEPPS, MITF, NR2E3 | PDK2 4156/4885LMNA 2621/4885HTT 1684/4885 |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | IPO4, NPM1, PPOX | PDK2 3531/4885LMNA 607/4885HTT 1651/4885 |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | IPO5, IPO4, NQO1 | PDK2 2215/4885LMNA 224/4885HTT 1279/4885 |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | IPO5, IPO4, NQO1 | PDK2 2215/4885LMNA 224/4885HTT 1279/4885 |
| US-20120053341-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | MITF, NPEPPS, GNE | PDK2 4268/4885LMNA 1812/4885HTT 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.