Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29349096 | 0.74 | CACNA2D1 (0.35) | CACNA2D1CYP1A2GAASLC6A2 | |
| SCHEMBL10407980 | 0.67 | NAAA (0.47) | GRM5ALOX12 | |
| SCHEMBL8469734 | 0.65 | POLB (0.51) | ALOX12 | |
| SCHEMBL9938444 | 0.64 | GRM5 (0.63) | GRM5GRM3CYP1A2 | |
| SCHEMBL7337665 | 0.62 | EPHX2 (0.43) | ALOX12GAA | |
| SCHEMBL9770647 | 0.60 | RAB9A (0.66) | GRM5GAA | |
| SCHEMBL21371330 | 0.60 | TSHR (0.44) | ALOX12GAA | |
| SCHEMBL9770539 | 0.60 | ALOX12 (0.54) | ALOX12 | |
| SCHEMBL2300940 | 0.59 | LTA4H (0.53) | — | |
| SCHEMBL12486958 | 0.59 | LTA4H (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651222-A1 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | Vanderbilt University (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012083224-A1 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2012-06-21 | — | — | WO | disclosed |