Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.46 |
| ▸ | CTSK | P43235 | 6/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | ACACA | Q13085 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3648358 | 0.92 | CTSK (0.49) | CTSSCTSKSYKATMCTSB | |
| SCHEMBL9536094 | 0.84 | SYK (0.39) | CTSSCTSKSYKATMMALT1 | |
| SCHEMBL9417108 | 0.84 | GAA (0.45) | CTSKSYKATMIDO1 | |
| SCHEMBL9533724 | 0.83 | SYK (0.51) | SYKHDAC1ACACB | |
| SCHEMBL6167126 | 0.82 | KDM4A (0.44) | CTSSCTSKSYKCTSBACACB | |
| SCHEMBL23453287 | 0.82 | GPR88 (0.46) | CTSSCTSKSYK | |
| SCHEMBL27414019 | 0.82 | CTSS (0.48) | CTSSCTSKSYKHDAC1ATM | |
| SCHEMBL3996179 | 0.79 | GAA (0.41) | CTSKIDO1 | |
| SCHEMBL9536355 | 0.79 | MEN1 (0.48) | CTSSCTSKSYKATMCKS1B | |
| SCHEMBL12954733 | 0.79 | SYK (0.47) | CTSSCTSKSYKHDAC1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651896-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |