Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257737 | 0.89 | ENPP2 (0.56) | SMN1; SMN2GLABACE1ATML3MBTL1 | |
| SCHEMBL9945921 | 0.85 | RORC (0.49) | SMN1; SMN2ATML3MBTL1ALDH1A1TDP1 | |
| SCHEMBL9945988 | 0.81 | THRA (0.43) | SMN1; SMN2GLABACE1L3MBTL1ALDH1A1 | |
| SCHEMBL182934 | 0.81 | ENPP2 (0.57) | SMN1; SMN2GLABACE1ATML3MBTL1 | |
| SCHEMBL1138420 | 0.76 | ENPP2 (0.48) | SMN1; SMN2GLAL3MBTL1ALDH1A1ENPP2 | |
| SCHEMBL3785500 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2GLABACE1ATML3MBTL1 | |
| SCHEMBL5477791 | 0.76 | ALDH1A1 (0.68) | SMN1; SMN2GLABACE1L3MBTL1ALDH1A1 | |
| SCHEMBL29956963 | 0.76 | ENPP2 (0.43) | SMN1; SMN2GLABACE1ATML3MBTL1 | |
| SCHEMBL31437865 | 0.76 | ENPP2 (0.59) | SMN1; SMN2L3MBTL1ALDH1A1CSNK2A1ENPP2 | |
| SCHEMBL9946040 | 0.76 | ENPP2 (0.56) | SMN1; SMN2L3MBTL1ALDH1A1ENPP2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | SMN1; SMN2 3273/4885GLA 4681/4885BACE1 2686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.