SCHEMBL9952142

SCHEMBL9952142

CNc1ccc(C(F)(F)C(F)(F)F)cn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 1/20 0.42
NNMT P40261 1/20 0.41
RAB9A P51151 4/20 0.37
GAA P10253 3/20 0.37
POLB P06746 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
XPO1 O14980 1/20 0.37
NPC1 O15118 3/20 0.36
PTGS1 P23219 1/20 0.36
EGFR P00533 1/20 0.35
MEN1 O00255 1/20 0.35
MAPT P10636 1/20 0.35
GFER P55789 1/20 0.35
CDK5 Q00535 1/20 0.35
KMT2A Q03164 1/20 0.35
CDK5R1 Q15078 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDO2 P48775 1/20 0.35
DEGS1 O15121 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30826962 0.84 RAB9A (0.49) HCAR3NNMTRAB9AGAAPOLB
SCHEMBL116298 0.84 RAB9A (0.49) HCAR3NNMTRAB9AGAAPOLB
Hydrochloric Acid SCHEMBL28506287 0.82 RAB9A (0.48) HCAR3NNMTRAB9AGAAPOLB
Hydrochloric Acid SCHEMBL28538817 0.82 RAB9A (0.48) HCAR3NNMTRAB9AGAAPOLB
SCHEMBL15426484 0.82 HCAR3 (0.43) HCAR3NNMTRAB9AGAAPOLB
SCHEMBL12019745 0.78 HCAR3 (0.46) HCAR3NNMTRAB9AGAAALDH1A1
SCHEMBL21016713 0.74 HCAR3 (0.47) HCAR3NNMTRAB9AGAAPOLB
SCHEMBL21017072 0.74 NNMT (0.46) HCAR3NNMTRAB9AGAAPOLB
SCHEMBL1310898 0.74 ADRA2A (0.34) ALDH1A1MAPTKMT2ASMN1; SMN2KCNH2
SCHEMBL21016495 0.70 BRAF (0.44) HCAR3NNMTMAPTTDO2DEGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103464-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2026-04-16 US disclosed
US-12435083-B2 Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2025-10-07 US disclosed
US-20240327414-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYL- SULFONE / SULFOXIMINE-PYRIDINE N-OXIDE DERIVATIVES Boehringer Ingelheim Animal Health USA Inc. 2024-10-03 US disclosed
WO-2024175558-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYL-SULFONE/SULFOXIMINE-PYRIDINE N-OXIDE DERIVATIVES BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2024-08-29 WO disclosed
WO-2024175557-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYL-SULFOXIME-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2024-08-29 WO disclosed
CN-118355004-A Cyclopropyl- (heteroaryl) -substituted ethylsulfonyl-pyridine derivatives 勃林格殷格翰动物保健有限公司 2024-07-16 CN disclosed
US-20230234951-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2023-07-27 US disclosed
US-20230234951-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2023-07-27 US disclosed
US-20230234951-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2023-07-27 US disclosed
WO-2023036934-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYLPYRIDINE DERIVATIVES BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-03-16 WO disclosed
EP-2865672-A1 FUSED HETEROCYCLIC COMPOUND Sumitomo Chemical Co., Ltd (JP) 2015-04-29 EP disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed
EP-2655337-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF Sumitomo Chemical Company Limited (JP) 2013-10-30 EP disclosed
WO-2012086848-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-28 WO disclosed
WO-2012086848-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 HCAR3 246/4885NNMT 1995/4885RAB9A 694/4885
US-20230234951-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES CYCS, CYP2E1, AHR HCAR3 810/4885NNMT 1414/4885RAB9A 907/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 HCAR3 255/4885NNMT 1923/4885RAB9A 697/4885
US-20240327414-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYL- SULFONE / SULFOXIMINE-PYRIDINE N-OXIDE DERIVATIVES SQOR, PNPO, STS HCAR3 2666/4885NNMT 200/4885RAB9A 2354/4885
US-12435083-B2 Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives CYCS, CYP2E1, CYP1A1 HCAR3 884/4885NNMT 1574/4885RAB9A 913/4885
US-20260103464-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES CBR3, CYCS, CBR1 HCAR3 156/4885NNMT 4386/4885RAB9A 674/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.