Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953121 | 0.77 | TAAR1 (0.35) | MEN1KMT2ALMNADRD2DRD3 | |
| SCHEMBL9952815 | 0.73 | PDE4B (0.41) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL9952766 | 0.72 | DRD3 (0.33) | MEN1KMT2ALMNADRD2DRD3 | |
| SCHEMBL9952863 | 0.71 | MTNR1A (0.38) | MEN1KMT2ALMNADRD2DRD3 | |
| SCHEMBL21248842 | 0.69 | LMNA (0.56) | MEN1KMT2AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL14742669 | 0.69 | IMPDH2 (0.37) | MEN1KMT2ALMNADRD2DRD3 | |
| SCHEMBL14742518 | 0.69 | IMPDH2 (0.37) | MEN1KMT2ALMNADRD2DRD3 | |
| SCHEMBL9952960 | 0.69 | DRD2 (0.31) | MEN1KMT2ALMNADRD2DRD3 | |
| SCHEMBL9952461 | 0.69 | DRD2 (0.31) | MEN1KMT2ALMNADRD2DRD3 | |
| SCHEMBL9952761 | 0.69 | IMPDH2 (0.37) | MEN1KMT2ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |