Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14742490 | 0.83 | DRD2 (0.32) | CYP1A2CYP2D6CYP2C9KMT2ASLC2A1 | |
| SCHEMBL9952766 | 0.82 | DRD3 (0.33) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL15995290 | 0.81 | CHRNB2 (0.33) | — | |
| SCHEMBL9952992 | 0.77 | IMPDH2 (0.37) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL9952473 | 0.75 | IMPDH2 (0.41) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL9952859 | 0.74 | PIK3CD (0.36) | MTNR1AMTNR1BROCK2ROCK1KDM4E | |
| SCHEMBL14742563 | 0.74 | IMPDH2 (0.33) | CYP1A2CYP2D6CYP2C9KMT2ASLC2A1 | |
| SCHEMBL14742446 | 0.74 | CHRNB2 (0.35) | SLC6A4DRD2KDM4EALDH1A1GAA | |
| SCHEMBL9952618 | 0.73 | P2RX7 (0.37) | KMT2ASLC2A1SHMT2DRD3DRD2 | |
| SCHEMBL9953206 | 0.73 | IMPDH2 (0.34) | DRD3DRD2IMPDH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |