Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955177 | 0.87 | ALPL (0.56) | ALPLDGAT1AAK1ALDH1A1PIK3CD | |
| SCHEMBL14317989 | 0.85 | ALPL (0.59) | ALPLPOLBGAADGAT1AAK1 | |
| SCHEMBL9953535 | 0.84 | ALPL (0.57) | ALPLDGAT1AAK1PIK3CDPIK3CA | |
| SCHEMBL9953472 | 0.82 | ALPL (0.62) | ALPLDGAT1AAK1PIK3CDPIK3CA | |
| SCHEMBL9953888 | 0.82 | ALPL (0.56) | ALPLDGAT1AAK1PIK3CDPIK3CA | |
| SCHEMBL9953313 | 0.81 | ALPL (0.55) | ALPLDGAT1AAK1ALDH1A1HTT | |
| SCHEMBL9954091 | 0.80 | ALPL (0.61) | ALPLPOLBPKMCYP2C19DGAT1 | |
| SCHEMBL798817 | 0.80 | ALPL (0.60) | ALPLDGAT1AAK1ALDH1A1PIK3CD | |
| SCHEMBL9954248 | 0.79 | ALPL (0.54) | ALPLDGAT1AAK1TSHRGSK3A | |
| SCHEMBL9952979 | 0.79 | ALPL (0.53) | ALPLDGAT1AAK1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |