SCHEMBL9955019

SCHEMBL9955019

COc1ccc(C=CCc2ccc(C)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 2/20 0.67
ACHE P22303 1/20 0.52
TP53 P04637 3/20 0.50
ALDH1A1 P00352 2/20 0.50
CYP3A4 P08684 2/20 0.50
TSHR P16473 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
ALOX15 P16050 1/20 0.50
ALOX12 P18054 1/20 0.50
MAOA P21397 1/20 0.50
MAOB P27338 1/20 0.50
LMNA P02545 1/20 0.48
KDM4E B2RXH2 1/20 0.48
TRPA1 O75762 1/20 0.47
MAPT P10636 1/20 0.47
THRB P10828 1/20 0.47
RAB9A P51151 1/20 0.47
TUBB1 Q9H4B7 2/20 0.46
ESR1 P03372 2/20 0.46
ABL1 P00519 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9955015 1.00 RELA (0.67) RELAACHETP53ALDH1A1CYP3A4
SCHEMBL11429370 0.93 CYP3A4 (0.57) RELATP53ALDH1A1CYP3A4TSHR
SCHEMBL16093275 0.87 ACHE (0.62) RELAACHETP53ALDH1A1CYP3A4
SCHEMBL6546952 0.87 NFE2L2 (0.46) RELASMN1; SMN2MAPTRAB9AALOX5
SCHEMBL28508047 0.87 NFE2L2 (0.46) RELASMN1; SMN2MAPTRAB9AALOX5
SCHEMBL5134572 0.85 MAOA (0.51) RELATP53ALDH1A1CYP3A4TSHR
SCHEMBL5134571 0.85 MAOA (0.51) RELATP53ALDH1A1CYP3A4TSHR
SCHEMBL22525324 0.85 CYP1A1 (0.54) RELATP53ALDH1A1CYP3A4TSHR
SCHEMBL15105021 0.84 TRPA1 (0.63) RELATP53ALDH1A1CYP3A4TSHR
SCHEMBL3869325 0.84 TRPA1 (0.63) RELATP53ALDH1A1CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655307-B1 COMPOUNDS CAPABLE OF RELEASING FRAGRANT COMPOUNDS GIVAUDAN SA (CH) 2018-08-01 EP claimed
US-9193935-B2 Compounds capable of releasing fragrant compounds GIVAUDAN S.A. (CH) 2015-11-24 US claimed
US-20130316938-A1 Compounds Capable Of Releasing Fragrant Compounds GIVAUDAN S.A. (CH) 2013-11-28 US claimed
EP-2655307-A1 COMPOUNDS CAPABLE OF RELEASING FRAGRANT COMPOUNDS Givaudan SA (CH) 2013-10-30 EP claimed
WO-2012085287-A1 COMPOUNDS CAPABLE OF RELEASING FRAGRANT COMPOUNDS GIVAUDAN SA (CH) 2012-06-28 WO claimed
EP-2655307-B1 COMPOUNDS CAPABLE OF RELEASING FRAGRANT COMPOUNDS GIVAUDAN SA (CH) 2018-08-01 EP disclosed
US-9193935-B2 Compounds capable of releasing fragrant compounds GIVAUDAN S.A. (CH) 2015-11-24 US disclosed
US-8927685-B1 Thermoset and thermoplastic compositions derived from the essential oils of herbs THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2015-01-06 US disclosed
US-8841405-B1 Thermoset and thermoplastic compositions derived from the essential oils of herbs THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2014-09-23 US disclosed
US-20130316938-A1 Compounds Capable Of Releasing Fragrant Compounds GIVAUDAN S.A. (CH) 2013-11-28 US disclosed
EP-2655307-A1 COMPOUNDS CAPABLE OF RELEASING FRAGRANT COMPOUNDS Givaudan SA (CH) 2013-10-30 EP disclosed
WO-2012085287-A1 COMPOUNDS CAPABLE OF RELEASING FRAGRANT COMPOUNDS GIVAUDAN SA (CH) 2012-06-28 WO disclosed