Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15724363 | 0.83 | CYP1A2 (0.33) | LMNAPDE4DL3MBTL1ALDH1A1P2RX7 | |
| SCHEMBL23294471 | 0.78 | KDM4C (0.50) | LMNAMEN1KMT2APDE4DL3MBTL1 | |
| SCHEMBL15824828 | 0.77 | DYRK1A (0.44) | HCAR2DAOLMNAMEN1KMT2A | |
| SCHEMBL30107036 | 0.76 | HCAR2 (0.42) | HCAR2DAOLMNAMEN1KMT2A | |
| SCHEMBL15230490 | 0.75 | PDE4D (0.56) | MEN1KMT2APDE4DALDH1A1HPGD | |
| SCHEMBL31469596 | 0.74 | HCAR2 (0.37) | HCAR2DAOMEN1KMT2AGPR35 | |
| SCHEMBL3949817 | 0.74 | HCAR2 (0.48) | HCAR2DAOLMNAMEN1KMT2A | |
| SCHEMBL14879418 | 0.74 | HCAR2 (0.48) | HCAR2DAOLMNAMEN1KMT2A | |
| SCHEMBL17479406 | 0.74 | HCAR2 (0.40) | HCAR2LMNAMEN1KMT2ARAB9A | |
| SCHEMBL19635846 | 0.71 | HCAR2 (0.36) | HCAR2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3157938-B1 | HETERO FUNCTIONAL BINDING SYSTEMS | ANTEO TECH PTY LTD (AU) | 2022-03-16 | — | — | EP | disclosed |
| EP-3186224-B1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | HOFFMANN LA ROCHE (CH) | 2021-04-21 | — | — | EP | disclosed |
| US-10768176-B2 | Hetero functional binding systems | ANTEO TECHNOLOGIES PTY LTD (AU) | 2020-09-08 | — | — | US | disclosed |
| CN-107001259-B | Substituted azetidine derivatives as TAAR ligands | 豪夫迈·罗氏有限公司 | 2019-12-06 | — | — | CN | disclosed |
| US-10106523-B2 | Amide compound | ASTELLAS PHARMA INC. (JP) | 2018-10-23 | — | — | US | disclosed |
| US-10023559-B2 | Substituted azetidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| EP-3124480-B1 | AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2018-07-11 | — | — | EP | disclosed |
| US-20180030030-A1 | AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2018-02-01 | — | — | US | disclosed |
| US-20180030030-A1 | AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2018-02-01 | — | — | US | disclosed |
| EP-3186224-A1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | F. Hoffmann-La Roche AG (CH) | 2017-07-05 | — | — | EP | disclosed |
| US-20170144994-A1 | SUBSTITUTED AZETIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-20170115285-A1 | HETERO FUNCTIONAL BINDING SYSTEMS | ANTEO TECHNOLOGIES PTY LTD (AU) | 2017-04-27 | — | — | US | disclosed |
| EP-3157938-A1 | HETERO FUNCTIONAL BINDING SYSTEMS | Anteo Technologies Pty Ltd. (AU) | 2017-04-26 | — | — | EP | disclosed |
| EP-3124480-A1 | AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2017-02-01 | — | — | EP | disclosed |
| EP-3124480-A1 | AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2017-02-01 | — | — | EP | disclosed |
| WO-2016030310-A1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-03-03 | — | — | WO | disclosed |
| WO-2015192183-A1 | HETERO FUNCTIONAL BINDING SYSTEMS | ANTEO TECHNOLOGIES PTY LTD (AU) | 2015-12-23 | — | — | WO | disclosed |
| EP-2655323-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012083953-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO PHARMA A/S (DK) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023559-B2 | Substituted azetidine derivatives | HTR1B, MTNR1B, DRD2 | HCAR2 593/4885DAO 995/4885LMNA 1686/4885 |
| US-20170144994-A1 | SUBSTITUTED AZETIDINE DERIVATIVES | HTR1B, MTNR1B, DRD2 | HCAR2 593/4885DAO 995/4885LMNA 1686/4885 |
| US-10106523-B2 | Amide compound | REN, GLS, ATP6V1B1 | HCAR2 446/4885DAO 1093/4885LMNA 3607/4885 |
| US-20180030030-A1 | AMIDE COMPOUND | PTGER4, PTGER1, PTGER2 | HCAR2 84/4885DAO 2733/4885LMNA 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.