Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959530 | 0.91 | ALDH1A1 (0.43) | HPGDRAB9AMAPK1MEN1KMT2A | |
| SCHEMBL9952739 | 0.86 | HPGD (0.54) | HPGDPOLBRAB9AMAPK1MEN1 | |
| SCHEMBL10153686 | 0.84 | MEN1 (0.46) | HPGDPOLBRAB9AMEN1KMT2A | |
| SCHEMBL10153706 | 0.83 | PRMT5 (0.43) | POLBRAB9AMEN1KMT2AMAPT | |
| SCHEMBL10153721 | 0.81 | KDR (0.47) | MAPT | |
| SCHEMBL9958824 | 0.80 | ALDH1A1 (0.44) | POLBRAB9AMEN1KMT2AMAPT | |
| SCHEMBL9959556 | 0.79 | PRMT5 (0.46) | POLBMEN1KMT2APKMMAPT | |
| SCHEMBL9952468 | 0.79 | ALDH1A1 (0.50) | HPGDPOLBRAB9AMAPK1MEN1 | |
| SCHEMBL10154072 | 0.78 | MAPT (0.52) | HPGDPOLBKMT2AMAPTALDH1A1 | |
| SCHEMBL9959528 | 0.76 | L3MBTL1 (0.37) | RAB9AMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |