Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958549 | 0.84 | HPGD (0.46) | MEN1KMT2AHPGDALDH1A1POLB | |
| SCHEMBL10153594 | 0.84 | ACHE (0.45) | MEN1KMT2AALDH1A1RAB9AKDM4E | |
| SCHEMBL10153293 | 0.82 | ACHE (0.45) | MEN1KMT2APOLBCTDSP1RAB9A | |
| SCHEMBL9959325 | 0.81 | APP (0.42) | MEN1KMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL10153305 | 0.79 | MEN1 (0.46) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL10153995 | 0.79 | GRM4 (0.44) | RAB9AKDM4EMAPTNPC1PKM | |
| SCHEMBL10153644 | 0.77 | ALDH1A1 (0.42) | HPGDALDH1A1HSD17B10L3MBTL1RAB9A | |
| SCHEMBL10153698 | 0.77 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL9959247 | 0.77 | ALDH1A1 (0.42) | MEN1KMT2AHPGDALDH1A1POLB | |
| SCHEMBL9960564 | 0.77 | TRPA1 (0.38) | MEN1KMT2AALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |