Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SQLE | Q14534 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | TERT | O14746 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29284415 | 0.96 | TSHR (0.61) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL8385489 | 0.92 | TSHR (0.56) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL8385488 | 0.92 | TSHR (0.56) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL29284458 | 0.92 | TSHR (0.56) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL29284307 | 0.92 | TSHR (0.56) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL29284196 | 0.92 | TSHR (0.56) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL999077 | 0.90 | TSHR (0.64) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL29284342 | 0.90 | TSHR (0.56) | TSHRALDH1A1MAPTABCC4LMNA | |
| SCHEMBL25404141 | 0.88 | SQLE (0.52) | MAPTLMNASQLELSSFAAH | |
| SCHEMBL5699227 | 0.88 | SQLE (0.52) | MAPTLMNASQLELSSFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230099694-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-03-30 | — | — | US | disclosed |
| US-20210052575-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-02-25 | — | — | US | disclosed |
| US-20200061056-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-02-27 | — | — | US | disclosed |
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
| US-20180318294-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-11-08 | — | — | US | disclosed |
| US-20180092907-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-04-05 | — | — | US | disclosed |
| EP-2151233-B1 | TWO-COMPONENT OXIDATIVE HAIR DYE COMPOSITION | KAO CORP (JP) | 2017-08-09 | — | — | EP | disclosed |
| EP-2151232-B1 | OXIDATIVE HAIR DYE COMPOSITION | KAO CORP (JP) | 2017-04-12 | — | — | EP | disclosed |
| US-20170071933-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-03-16 | — | — | US | disclosed |
| EP-2753617-B9 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMA CO LTD (JP) | 2017-01-25 | — | — | EP | disclosed |
| EP-1468665-A2 | Hair cosmetic composition | Kao Corporation (JP) | 2004-10-20 | — | — | EP | disclosed |
| US-20040166084-A1 | Hair cosmetic composition | KAO CORPORATION (JP) | 2004-08-26 | — | — | US | disclosed |
| US-20040156815-A1 | Hair cleansing composition | KAO CORPORATION (JP) | 2004-08-12 | — | — | US | disclosed |
| US-20040157984-A1 | Hair cleansing composition | KAO CORPORATION (JP) | 2004-08-12 | — | — | US | disclosed |
| EP-1433464-A2 | Hair cleansing composition | Kao Corporation (JP) | 2004-06-30 | — | — | EP | disclosed |
| EP-1433465-A2 | Hair cosmetic composition | Kao Corporation (JP) | 2004-06-30 | — | — | EP | disclosed |
| EP-1433466-A2 | Hair cleansing composition | Kao Corporation (JP) | 2004-06-30 | — | — | EP | disclosed |
| US-20040115162-A1 | Dermatological preparations | KAO CORPORATION (JP) | 2004-06-17 | — | — | US | disclosed |
| US-6685953-B1 | WATER RETENTION CAPACITY; MOISTURIZER; ALKOXYALKYAMIDES OF ALKYLENEDICARBOXYLIC ACIDS | KAO CORPORATION (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-1166766-A1 | EXTERNAL PREPARATION COMPOSITIONS | Kao Corporation (JP) | 2002-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230099694-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | TSHR 1644/4885ALDH1A1 1257/4885MAPT 157/4885 |
| US-20170071933-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | TSHR 1644/4885ALDH1A1 1257/4885MAPT 157/4885 |
| US-20180318294-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | TSHR 1644/4885ALDH1A1 1257/4885MAPT 157/4885 |
| US-20210052575-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, SULT2A1, CYP4Z1 | TSHR 1868/4885ALDH1A1 1445/4885MAPT 422/4885 |
| US-20200061056-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | TSHR 1644/4885ALDH1A1 1257/4885MAPT 157/4885 |
| US-20040166084-A1 | Hair cosmetic composition | H1-0, H1-2, SHH | TSHR 1526/4885ALDH1A1 1808/4885MAPT 3473/4885 |
| US-20180092907-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | TSHR 1644/4885ALDH1A1 1257/4885MAPT 157/4885 |
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | TSHR 1644/4885ALDH1A1 1257/4885MAPT 157/4885 |
| US-20040156815-A1 | Hair cleansing composition | CUTA, TRPA1, SHH | TSHR 2228/4885ALDH1A1 2683/4885MAPT 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.