Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 6/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086333 | 0.87 | CCR2 (0.55) | KDM4ESMN1; SMN2CCR2TYMSGALR3 | |
| SCHEMBL6084959 | 0.84 | MEN1 (0.49) | KDM4ESMN1; SMN2CCR2TYMSGALR3 | |
| SCHEMBL9959670 | 0.82 | HDAC1 (0.45) | KDM4ECCR2TYMSGALR3NR2F2 | |
| SCHEMBL9959205 | 0.82 | MEN1 (0.56) | KDM4ESMN1; SMN2ALDH1A1CCR2TYMS | |
| SCHEMBL9958540 | 0.82 | BRD4 (0.48) | KDM4ESMN1; SMN2ALDH1A1CCR2TYMS | |
| SCHEMBL6823866 | 0.81 | CCR2 (0.52) | CCR2GALR3NR2F2RAB9AHDAC1 | |
| SCHEMBL9959873 | 0.81 | DRD2 (0.46) | KDM4EALDH1A1HSD17B10CCR2TYMS | |
| SCHEMBL6086266 | 0.80 | HDAC1 (0.62) | KDM4ESMN1; SMN2ALDH1A1CCR2TNF | |
| SCHEMBL6085520 | 0.79 | CCR2 (0.56) | KDM4EALDH1A1CCR2PTGS2MDM4 | |
| SCHEMBL9958509 | 0.79 | CCR2 (0.44) | KDM4EALDH1A1CCR2TYMSGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657012-B2 | FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| EP-2655356-B1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS INC (US) | 2016-08-03 | — | — | EP | disclosed |
| CN-103502237-B | Faah inhibitor | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-01-20 | — | — | CN | disclosed |
| US-20150175599-A1 | FAAH Inhibitors | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-06-25 | — | — | US | disclosed |
| CN-103502237-A | FAAH inhibitors | IRONWOOD PHARMACEUTICALS INC | 2014-01-08 | — | — | CN | disclosed |
| EP-2655356-A1 | FAAH INHIBITORS | Ironwood Pharmaceuticals, Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012088469-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175599-A1 | FAAH Inhibitors | FAAH, FAAH2, ASAH1 | KDM4E 2260/4885SMN1; SMN2 1869/4885ALDH1A1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.