Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23242265 | 0.87 | TRPA1 (0.33) | ALDH1A1KDM4ENPSR1HPGDTRPA1 | |
| SCHEMBL15804376 | 0.82 | ALDH1A1 (0.42) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL14315820 | 0.81 | KDM4E (0.46) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL16222497 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL3920626 | 0.81 | ALDH1A1 (0.41) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL669045 | 0.81 | ALDH1A1 (0.41) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL29868208 | 0.81 | ALDH1A1 (0.41) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL22229789 | 0.81 | KDM4E (0.37) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL15206461 | 0.80 | HSD11B1 (0.39) | ALDH1A1KDM4ENPSR1HPGDMAPT | |
| SCHEMBL6130240 | 0.78 | GPR84 (0.42) | ALDH1A1KDM4ENPSR1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975447-B2 | Process for asymetric methylallylation in the presence of a 2,2′-substituted 1,1′-BI-2-naphthol catalyst | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-10 | — | — | US | disclosed |
| US-8975447-B2 | Process for asymetric methylallylation in the presence of a 2,2′-substituted 1,1′-BI-2-naphthol catalyst | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-10 | — | — | US | disclosed |
| US-8975447-B2 | Process for asymetric methylallylation in the presence of a 2,2′-substituted 1,1′-BI-2-naphthol catalyst | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-10 | — | — | US | disclosed |
| US-8916701-B2 | Methods of making diastereomeric organic compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-23 | — | — | US | disclosed |
| US-8916701-B2 | Methods of making diastereomeric organic compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-23 | — | — | US | disclosed |
| US-8916701-B2 | Methods of making diastereomeric organic compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-23 | — | — | US | disclosed |
| EP-2655349-B1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-15 | — | — | EP | disclosed |
| EP-2655349-B1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-15 | — | — | EP | disclosed |
| US-20140171692-A1 | PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2,2'-SUBSTITUTED 1,1'-BI -2-NAPHTHOL CATALYST | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-19 | — | — | US | disclosed |
| US-20140171692-A1 | PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2,2'-SUBSTITUTED 1,1'-BI -2-NAPHTHOL CATALYST | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-19 | — | — | US | disclosed |
| US-20140171692-A1 | PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2,2'-SUBSTITUTED 1,1'-BI -2-NAPHTHOL CATALYST | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-19 | — | — | US | disclosed |
| US-20140135493-A1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-15 | — | — | US | disclosed |
| US-20140135493-A1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-15 | — | — | US | disclosed |
| US-20140135493-A1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-15 | — | — | US | disclosed |
| EP-2655349-A1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012122152-A1 | PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2, 2 ' - SUBSTITUTED 1, 1 ' -BI - 2 -NAPHTHOL CATALYST | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012087720-A1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087720-A1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171692-A1 | PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2,2'-SUBSTITUTED 1,1'-BI -2-NAPHTHOL CATALYST | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 111/4885KDM4E 941/4885NPSR1 803/4885 |
| US-20140135493-A1 | METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 74/4885KDM4E 2119/4885NPSR1 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.