Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.92 |
| ▸ | TP53 | P04637 | 1/20 | 0.92 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.75 |
| ▸ | CA1 | P00915 | 3/20 | 0.71 |
| ▸ | CA2 | P00918 | 3/20 | 0.71 |
| ▸ | CA12 | O43570 | 1/20 | 0.71 |
| ▸ | CA3 | P07451 | 1/20 | 0.71 |
| ▸ | TYR | P14679 | 1/20 | 0.71 |
| ▸ | DRD1 | P21728 | 1/20 | 0.71 |
| ▸ | CA4 | P22748 | 1/20 | 0.71 |
| ▸ | CA6 | P23280 | 1/20 | 0.71 |
| ▸ | CA5A | P35218 | 1/20 | 0.71 |
| ▸ | CA7 | P43166 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.71 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.71 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.69 |
| ▸ | DAO | P14920 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL28830666 | 0.96 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL4450034 | 0.96 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL5053781 | 0.96 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL175823 | 0.96 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL1655 | 0.96 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL2511919 | 0.96 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL25381766 | 0.92 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL1065024 | 0.92 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL1010632 | 0.92 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL20704876 | 0.92 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 523 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12139608-B2 | Non-halogenated flame retardant polyamide compositions | ASCEND PERFORMANCE MATERIALS OPERATIONS LLC (US) | 2024-11-12 | — | — | US | claimed |
| CN-114685844-A | Preparation method of efficient oil-water separation sponge | 中国石油大学(华东) | 2022-07-01 | — | — | CN | claimed |
| EP-3947563-A1 | NON-HALOGENATED FLAME RETARDANT POLYAMIDE COMPOSITIONS | Ascend Performance Materials Operations LLC (US) | 2022-02-09 | — | — | EP | claimed |
| CN-113661214-A | Non-halogenated flame retardant polyamide composition | 奥升德功能材料运营有限公司 | 2021-11-16 | — | — | CN | claimed |
| CN-112011705-A | Batch preparation method of nano-carbon reinforced copper-based composite material | 哈尔滨工业大学 | 2020-12-01 | — | — | CN | claimed |
| CN-112011706-A | Batch preparation method of carbon nanosheet reinforced copper-based composite material | 哈尔滨工业大学 | 2020-12-01 | — | — | CN | claimed |
| WO-2020205988-A1 | NON-HALOGENATED FLAME RETARDANT POLYAMIDE COMPOSITIONS | ASCEND PERFORMANCE MATERIALS OPERATIONS LLC (US) | 2020-10-08 | — | — | WO | claimed |
| US-20200308402-A1 | NON-HALOGENATED FLAME RETARDANT POLYAMIDE COMPOSITIONS | ASCEND PERFORMANCE MATERIALS OPERATIONS LLC (US) | 2020-10-01 | — | — | US | claimed |
| CN-108878158-B | Preparation method and application of carbon-based composite material | 中国科学院福建物质结构研究所 | 2020-02-21 | — | — | CN | claimed |
| US-20190276476-A1 | TWO-DIMENSIONAL METAL-ORGANIC-FRAMEWORKS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | 2019-09-12 | — | — | US | claimed |
| CN-103059050-A | Terephthalic acid copper complex with catalytic activity as well as preparation and application methods | UNIV NORTH CHINA | 2013-04-24 | — | — | CN | claimed |
| CN-101475790-B | Novel timber adhesive and preparation thereof | GUANG YANG | 2012-10-10 | — | — | CN | claimed |
| EP-2502671-A2 | CRYSTALLINE POROUS ORGANIC-INORGANIC HYBRID MATERIAL AND A PRODUCTION METHOD THEREFOR | Korea Research Institute Of Chemical Technology (KR) | 2012-09-26 | — | — | EP | claimed |
| US-20110118490-A1 | Porous Organic-Inorganic Hybrid Materials with Crystallinity and Method for Preparing Thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KP) | 2011-05-19 | — | — | US | claimed |
| US-20110067426-A1 | Apparatus for Treating Air | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KP) | 2011-03-24 | — | — | US | claimed |
| CN-101475790-A | Novel timber adhesive and preparation thereof | GUANG YANG (CN) | 2009-07-08 | — | — | CN | claimed |
| EP-0727608-B1 | Gas storage apparatus, gaseous fuel automobile using the gas storage apparatus, gas storage method and methane adsorbing-retaining agent | OSAKA GAS CO LTD (JP) | 2004-09-01 | — | — | EP | claimed |
| US-5862796-A | Gas storage apparatus, gaseous fuel automobile using the gas storage apparatus, gas storage method and methane adsorbing-retaining agent | OSAKA GAS CO., LTD. (JP) | 1999-01-26 | — | — | US | claimed |
| EP-0727608-A2 | Gas storage apparatus, gaseous fuel automobile using the gas storage apparatus, gas storage method and methane adsorbing-retaining agent | OSAKA GAS CO., LTD. (JP) | 1996-08-21 | — | — | EP | claimed |
| US-3961933-A | ALGICIDAL COMPOSITION FOR NON-MEDICAL USESMICROBIOCIDES, COPPER TEREPHTHALATE AND ISOPHTHALATE, INORGANIC COPPER SALT | TOKYO ORGANIC CHEMICAL INDUSTRIES, INC. (JA) | 1976-06-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118490-A1 | Porous Organic-Inorganic Hybrid Materials with Crystallinity and Method for Preparing Thereof | ATM, TPR, BMP2 | TSHR 4542/4885TP53 221/4885SRD5A2 3291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.