Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.86 |
| ▸ | TP53 | P04637 | 1/20 | 0.86 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.71 |
| ▸ | CA1 | P00915 | 3/20 | 0.67 |
| ▸ | CA2 | P00918 | 3/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA3 | P07451 | 1/20 | 0.67 |
| ▸ | TYR | P14679 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.65 |
| ▸ | DAO | P14920 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL11771938 | 0.96 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL31011418 | 0.96 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL2884946 | 0.96 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL996091 | 0.96 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27505341 | 0.96 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL25381766 | 0.96 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL9130691 | 0.93 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL28895258 | 0.93 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL28895260 | 0.93 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL29023833 | 0.93 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654418-B1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | NUTRIAG LTD (CA) | 2017-08-23 | — | — | EP | disclosed |
| US-9433208-B2 | Crop oil concentrate adjuvants containing amine surfactants | HUNTSMAN PETROCHEMICAL LLC (US) | 2016-09-06 | — | — | US | disclosed |
| US-9277747-B2 | Agricultural composition comprising pH sensitive agricultural chemicals and organic pH buffer | NUTRIAG LTD. (CA) | 2016-03-08 | — | — | US | disclosed |
| US-20140249032-A1 | Crop Oil Concentrate Adjuvants Containing Amine Surfactants | HUNTSMAN PETROCHEMICAL LLC (US) | 2014-09-04 | — | — | US | disclosed |
| US-8765637-B2 | Crop oil concentrate adjuvants containing amine surfactants | HUNTSMAN PETROCHEMICAL LLC (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2654418-A1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | Nutriag Ltd. (CA) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012083453-A1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | NUTRIAG LTD. (CA) | 2012-06-28 | — | — | WO | disclosed |
| US-20120157317-A1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | NUTRIAG LTD (CA) | 2012-06-21 | — | — | US | disclosed |
| EP-1399019-B1 | ADJUVANT COMPOSITIONS AND PESTICIDES | HUNTSMAN SPEC CHEM CORP (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20080020933-A1 | Crop Oil Concentrate Adjuvants Containing Amine Surfactants | INDORAMA VENTURES OXIDES LLC | 2008-01-24 | — | — | US | disclosed |
| WO-2006080917-A1 | SURFACE-ACTIVE POLYMERS - AGRICULTURAL APPLICATIONS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2006-08-03 | — | — | WO | disclosed |
| WO-2005084437-A1 | CROP OIL CONCENTRATE ADJUVANTS CONTAINING AMINE SURFACTANTS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |
| WO-2005060756-A1 | SURFACTANT ENHANCED QUICK RELEASE PESTICIDE GRANULES | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
| EP-1399019-A4 | ADJUVANT COMPOSITIONS AND PESTICIDES | HUNTSMAN SPEC CHEM CORP (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20040142823-A1 | Adjuvant compositions and pesticides | DEUTSCHE BANK TRUST COMPANY AMERICAS, AS AGENT | 2004-07-22 | — | — | US | disclosed |
| US-20040106523-A1 | Alkylene carbonate adjuvants | EDGECRAFT CORPORATION | 2004-06-03 | — | — | US | disclosed |
| EP-1399019-A1 | ADJUVANT COMPOSITIONS AND PESTICIDES | Huntsman Petrochemical Corporation (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003096807-A1 | AGRICULTURAL FORMULATIONS CONTAINING ENHANCED SURFACTANTS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| WO-2002098221-A1 | ADJUVANT COMPOSITIONS AND PESTICIDES | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2002-12-12 | — | — | WO | disclosed |
| WO-2002078441-A1 | ALKYLENE CARBONATE ADJUVANTS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080020933-A1 | Crop Oil Concentrate Adjuvants Containing Amine Surfactants | MLX, DDT, BMX | TSHR 2261/4885TP53 2589/4885SRD5A2 4063/4885 |
| US-20040142823-A1 | Adjuvant compositions and pesticides | ITPR3, ACHE, ORAI3 | TSHR 2796/4885TP53 155/4885SRD5A2 2650/4885 |
| US-20140249032-A1 | Crop Oil Concentrate Adjuvants Containing Amine Surfactants | MLX, DDT, MAX | TSHR 2367/4885TP53 2746/4885SRD5A2 3904/4885 |
| US-20040106523-A1 | Alkylene carbonate adjuvants | ACHE, CA3, PLCG2 | TSHR 2374/4885TP53 2434/4885SRD5A2 1594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.