Darenzepine

Darenzepine

SCHEMBL996265

CN1CCN(C(=O)/C=C2/c3ccccc3NC(=O)c3ccccc32)CC1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
ALDH1A1 P00352 5/20 0.51
MAPT P10636 4/20 0.51
SMN1; SMN2 Q16637 4/20 0.51
HTT P42858 2/20 0.51
LMNA P02545 1/20 0.51
TGM2 P21980 1/20 0.51
IDO1 P14902 1/20 0.51
NPSR1 Q6W5P4 2/20 0.50
KIT P10721 1/20 0.50
AURKB Q96GD4 1/20 0.50
KDM4E B2RXH2 1/20 0.50
PKM P14618 1/20 0.50
MAPK1 P28482 1/20 0.50
KDR P35968 2/20 0.46
PDGFRB P09619 1/20 0.46
FGFR1 P11362 1/20 0.46
RAB9A P51151 1/20 0.45
HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Darenzepine SCHEMBL9629094 1.00 MEN1 (0.52) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL10518957 0.85 KIT (0.48) ALDH1A1MAPTSMN1; SMN2HTTLMNA
SCHEMBL10524643 0.79 NPSR1 (0.46) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL5879643 0.76 MAPT (0.63) ALDH1A1MAPTSMN1; SMN2HTTLMNA
SCHEMBL5879640 0.76 MAPT (0.63) ALDH1A1MAPTSMN1; SMN2HTTLMNA
SCHEMBL5879639 0.76 MAPT (0.63) ALDH1A1MAPTSMN1; SMN2HTTLMNA
SCHEMBL9629102 0.76 KMT2A (0.46) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL30685721 0.73 MET (0.66) MEN1KMT2AKITAURKBKDR
SCHEMBL12143508 0.72 MAPT (0.58) ALDH1A1MAPTSMN1; SMN2HTTLMNA
SCHEMBL10517978 0.71 ALDH1A1 (0.41) MEN1KMT2AALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-3646870-B1 COMPOSITIONS FOR TREATMENT OF DISORDERS AMELIORATED BY MUSCARINIC RECEPTOR ACTIVATION PureTech Health LLC (US) 2026-05-20 EP disclosed
US-20260124147-A1 THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING MOVEMENT DISORDERS Vima Therapeutics, Inc. (US) 2026-05-07 US disclosed
US-20260102381-A1 Muscarinic Agent Combinations Syremis Therapeutics, Ltd. (IL) 2026-04-16 US disclosed
US-20250339418-A1 THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING MOVEMENT DISORDERS Vima Therapeutics, Inc. (US) 2025-11-06 US disclosed
US-20250268883-A1 THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING MOVEMENT DISORDERS Vima Therapeutics, Inc. (US) 2025-08-28 US disclosed
US-12290513-B2 Therapeutic methods and compositions for treating movement disorders Vima Therapeutics, Inc. (US) 2025-05-06 US disclosed
WO-2002045693-A1 PHARMACEUTICAL PREPARATION COMPRISING AN ACTIVE DISPERSED ON A MATRIX ALTANA PHARMA AG (DE) 2002-06-13 WO disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
EP-0538262-A1 N-DIMETHOXY PHENYL ALKYL-N'-IMIDAZOLYL PHENYL AMIDINE DERIVATIVES AND PROCESS THEREOF IL YANG PHARM. CO., LTD. (KR) 1993-04-28 EP disclosed
EP-0276735-B1 AQUEOUS OR WATER-DISPERSABLE POWDERY PREPARATION OF A SLIGHTLY WATER SOLUBLE PHARMACEUTICALLY ACTIVE AGENT, AND PROCESS FOR ITS PRODUCTION BASF Aktiengesellschaft (DE) 1992-04-01 EP disclosed
WO-1992000966-A1 N-DIMETHOXY PHENYL ALKYL-N'-IMIDAZOLYL PHENYL AMIDINE DERIVATIVES AND PROCESS THEREOF IL YANG PHARM. CO., LTD. (KR) 1992-01-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250268883-A1 THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING MOVEMENT DISORDERS CHRM3, CHRM5, CHRM2 MEN1 3746/4885KMT2A 847/4885ALDH1A1 2939/4885
US-12290513-B2 Therapeutic methods and compositions for treating movement disorders CHRM3, CHRM5, CHRM2 MEN1 3746/4885KMT2A 847/4885ALDH1A1 2939/4885
US-20260102381-A1 Muscarinic Agent Combinations CHRM1, CHRM4, CHRM2 MEN1 2940/4885KMT2A 4541/4885ALDH1A1 1598/4885
US-20250339418-A1 THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING MOVEMENT DISORDERS CHRM3, CHRM5, CHRM2 MEN1 3746/4885KMT2A 847/4885ALDH1A1 2939/4885
US-20260124147-A1 THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING MOVEMENT DISORDERS CHRM5, CHRM4, CHRM2 MEN1 4598/4885KMT2A 791/4885ALDH1A1 4439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.