Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9965449 | 0.81 | KDM4E (0.51) | HRH1SIGMAR1ALDH1A1LMNAKDM4E | |
| SCHEMBL9965463 | 0.80 | EPHX2 (0.40) | P2RX7LMNAKDM4ESMN1; SMN2ABCB11 | |
| SCHEMBL14639728 | 0.70 | EPHX2 (0.40) | TACR1HSD11B1POLBRIPK1 | |
| SCHEMBL18711673 | 0.68 | CCNC (0.49) | ALDH1A1HSD11B1POLBRIPK1 | |
| SCHEMBL24011067 | 0.67 | RIPK1 (0.68) | HSD11B1POLBRIPK1 | |
| SCHEMBL9965374 | 0.67 | PKM (0.38) | ALDH1A1LMNAKDM4EABCB11 | |
| SCHEMBL9201806 | 0.65 | TACR1 (0.54) | SMN1; SMN2TACR1RIPK1 | |
| SCHEMBL9201803 | 0.65 | TACR1 (0.54) | SMN1; SMN2TACR1RIPK1 | |
| SCHEMBL4242010 | 0.65 | L3MBTL1 (0.56) | ALDH1A1LMNASMN1; SMN2IDH1POLB | |
| SCHEMBL643314 | 0.65 | ABCB11 (0.38) | LMNAKDM4EABCB11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960347-B1 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (17BETA-HSD3) INHIBITORS | STERIX LTD (GB) | 2012-06-20 | — | — | EP | disclosed |